TABLE 3.

Compounds found in different concentrations in cases of premenstrual dysphoric disorder (PMDD) and controls. Compounds that narrowly missed statistical cutoff for significance 0.05 < P < 0.10 are also displayed

		Group ANOVA		Ratio of means cases/control		Group ANOVA at time 1		Group ANOVA at time 2
Biochemical	Pathway	P-value	Q-value	At time 1	At time 2	P-value	Q-value	P-value	Q-value
Alanine	Alanine and aspartate metabolism	0.134	0.775	0.76	0.97	0.059	0.732	0.865	0.681
N-acetyl-L-aspartic acid		0.004	0.542	1.62	1.89	0.033	0.732	0.007	0.465
Isobar 6 valine, betaine	Leucine, isoleucine and valine metabolism	0.364	0.838	0.86	1.10	0.065	0.732	0.632	0.672
Tyrosine	Phenylalanine and tyrosine metabolism	0.566	0.877	0.95	1.23	0.492	0.997	0.095	0.596
N(5)-(Aminocarbonyl)-L-Ornithine	Urea cycle; arginine and proline metabolism	0.102	0.775	0.94	0.72	0.633	0.997	0.028	0.596
Trans-4-hydroxyproline		0.254	0.807	1.07	1.57	0.906	0.997	0.056	0.596
Glycerol-2-phosphatase	Glycolysis, gluconeogenesis, and pyruvate metabolism	0.012	0.542	0.85	0.96	0.067	0.732	0.227	0.596
Glycerate		0.125	0.775	0.83	0.96	0.065	0.732	0.290	0.611
Alpha-D-ribose 5-phosphate	Pentose phosphate pathway	0.024	0.542	0.78	0.97	0.022	0.732	0.601	0.672
Biliverdin	Hemoglobin and porphyrin metabolism	0.325	0.807	1.35	0.96	0.996	0.997	0.084	0.596
Pyridoxamine	Vitamin B6 metabolism	0.015	0.542	0.91	0.81	0.219	0.930	0.003	0.307
Isobar 2 amino-butyrates	Pyrimidine metabolism, thymine containing	0.035	0.615	1.11	1.18	0.167	0.930	0.069	0.596
Uridine	Pyrimidine metabolism, uracil containing	0.051	0.723	0.74	0.79	0.054	0.732	0.189	0.596
Gamma-L-glutamyl-L-Tyrosine	Gamma-glutamyl amino acid	0.038	0.615	1.07	1.46	0.537	0.997	0.003	0.307
Caffeine	Xanthine metabolism	0.044	0.674	1.59	1.97	0.111	0.831	0.043	0.596

ANOVA, analysis of variance; time 1, after gonadal suppression; time 2, after progesterone add-back.

In bold: P ≤ 0.05.