TABLE 4.

Compounds with different changes in concentration at time 1 and time 2 between cases of premenstrual dysphoric disorder (PMDD) and controls (i.e., time by group interaction). If time 2/time 1 ratio is greater than 1, the compound was found in higher concentrations after progesterone administration than during gonadal suppression. If PMDD/CONTR ratio is greater than 1, the compound was found in higher concentrations in cases than in controls

				Fold-change (ratios of means from scaled imputed data)
		Group by time interaction ANOVA		Time 2/time 1		PMDD/CONTR
Biochemical	Pathway	P	Q	PMDD	Control	Time 1	Time2
Unknown compound	N/A	0.012	0.850	1.28	0.89	0.78	1.12
Tyrosine	Phenylalanine and tyrosine metabolism	0.020	0.850	1.05	0.82	0.95	1.23
Gamma-L-glutamyl-L-tyrosine	Gamma-glutamyl amino acid	0.022	0.850	1.14	0.83	1.07	1.46
Unknown compound	N/A	0.030	0.850	0.70	1.63	1.90	0.81
Citric acid	N/A	0.033	0.850	1.21	0.87	0.73	1.01
Unknown compound	N/A	0.036	0.850	1.25	0.80	0.60	0.93
Isoleucine	Leucine, Isoleucine and valine metabolism	0.040	0.850	1.44	0.85	0.87	1.49
Unknown compound	N/A	0.044	0.850	0.80	1.51	1.70	0.89
Carnitine-1	N/A	0.045	0.850	1.23	0.78	0.81	1.28
Trans-4-hydroxyproline	Urea cycle; arginine and proline metabolism	0.045	0.850	0.88	0.60	1.07	1.57
N(‘6)-trimethyl-L-lysine	Lysine metabolism	0.047	0.850	0.90	0.71	0.97	1.24
Unknown compound	N/A	0.049	0.850	0.82	1.00	1.21	0.99

ANOVA, analysis of variance; CONTR, controls; time 1, after gonadal suppression; time 2, after progesterone add-back.

In bold P ≤ 0.05.