Table 2.
Performance of FA-PP relative to conventional culture.
| Bacterial pathogen | FA-PP+ & culture+ | FA-PP+ & culture− | FA-PP− & culture+ | FA-PP− & culture− | Se (95% CI) | Sp (95% CI) | PPV (95% CI) | NPV (95% CI) | LR+ (95% CI) | LR− (95% CI) | κ coefficient (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Acinetobacter baumannii | 0 | 0 | 0 | 96 | - | 1.00 (−) |
- | 1.00 (−) |
- | - | 1.00 (−) |
| Staphylococcus aureus | 10 | 1 | 1 | 84 | 0.91 (0.58–1.0) |
0.99 (0.94–1.0) |
0.91 (0.59–0.98) |
0.99 (0.93–1.0) |
77 (11–547) |
0.09 (0.01–0.06) |
0.98 (0.93–1.0) |
| Streptococcus pneumoniae | 3 | 1 | 0 | 92 | 1.00 (0.29–1.0) |
0.99 (0.94–1.0) |
0.75 (0.30–0.95) |
1.00 (−) |
93 (13–653) |
0.00 (−) |
0.99 (0.94–1.0) |
| Escherichia coli | 3 | 0 | 0 | 93 | 1.00 (0.29–1.0) |
1.00 (0.96–1.0) |
1.00 (−) |
1.00 (−) |
- | 0.00 (−) |
1.00 (0.96–1.0) |
| Enterobacter cloacae | 0 | 1 | 0 | 95 | - | 0.99 (0.97–1.0) |
0.00 (−) |
1.00 (−) |
- | - | 0.99 (0.94–1.0) |
| Klebsiella aerogenes | 3 | 0 | 1 | 92 | 0.75 (0.19–0.99) |
1.00 (0.96–1.0) |
1.00 (−) |
0.99 (0.94–1.0) |
- | 0.25 (0.06–1.36) |
0.99 (0.94–1.0) |
| Klebsiella pneumoniae | 0 | 1 | 0 | 95 | - | 0.99 (0.97–1.0) |
0.00 (−) |
1.00 (−) |
- | - | 0.99 (0.94–1.0) |
| Klebsiella oxytoca | 0 | 0 | 0 | 96 | - | 1.00 (−) |
- | 1.00 (−) |
- | - | 1.00 (−) |
| Pseudomonas aeruginosa | 14 | 0 | 0 | 82 | 1.00 (0.77–1.0) |
1.00 (0.96–1.0) |
1.00 (−) |
1.00 (−) |
- | 0.00 (−) |
1.00 (0.96–1.0) |
| Haemophilus influenzae | 2 | 3 | 0 | 91 | 1.00 (0.16–1.0) |
0.97 (0.91–0.99) |
0.40 (0.18–0.67) |
1.00 (−) |
31 (10–95) |
0.00 (−) |
0.97 (0.91–0.99) |
| Streptococcus agalactiae | 1 | 0 | 0 | 95 | 1.00 (0.03–1.0) |
1.00 (0.96–1.0) |
1.00 (−) |
1.00 (−) |
- | 0.00 (−) |
1.00 (0.96–1.0) |
| Streptococcus pyogenes | 0 | 0 | 0 | 96 | - | 1.00 (−) |
- | 1.00 (−) |
- | - | 1.00 (−) |
| Serratia marcescens | 0 | 0 | 0 | 96 | - | 1.00 (−) |
- | 1.00 (−) |
- | - | 1.00 (−) |
| Proteus spp. | 0 | 1 | 0 | 95 | - | 0.99 (0.97–1.0) |
0.00 (−) |
1.00 (−) |
- | - | 0.99 (0.94–1.0) |
| Moraxella catarrhalis | 0 | 0 | 0 | 96 | - | 1.00 (−) |
- | 1.00 (−) |
- | - | 1.00 (−) |
| Total (per analysis) | 36 | 8 | 2 | 1394 | 0.95 (0.82–0.99) |
0.99 (0.99–1.0) |
0.82 (0.69–0.90) |
1.00 (0.99–1.0) |
166 (83–333) |
0.05 (0.01–0.20) |
0.99 (0.99–1.0) |
FA-PP = FilmArray Pneumonia Plus; Se = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value; LR = likelihood ratio.