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. 2020 Jul 13;39(34):5616–5632. doi: 10.1038/s41388-020-01388-8

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Tumor growth curves of shCtrl and sh1503 HK1 cells in xenograft tumor growth model. b Representative image of xenograft tumors. c Tumor weight was smaller in the sh1503 group than in the shCtrl group. d Representative image of primary tumor in foot pads and metastatic inguinal lymph nodes in the inguinal lymph node metastasis model. e Representative image of the inguinal lymph node. f Inguinal lymph node volume was smaller in the sh1503 group. g H&E staining of foot pad primary tumors. h Pan-cytokeratin staining for inguinal lymph nodes as tested by IHC assay. i The metastatic ratio of inguinal lymph nodes was smaller in the sh1503 group. j Representative images of metastatic nodules on the lungs in the lung metastatic colonization model. k The number of metastatic nodule in lungs was lower in the sh1503 group. l H&E staining showed that the metastatic nodules were fewer and smaller in the sh1503 group. Data are presented as the mean ± SD; p values were calculated with Student’s t test; *p < 0.05, **p < 0.01.