Table 1.
Baseline characteristics | Patient A | Patient B | Patient C | Patient D | Patient E | Patient F | Patient G | Patient H | Patient I |
---|---|---|---|---|---|---|---|---|---|
Age, years/sex | 45/F | 65/M | 73/F | 41/M | 69/M | 70/F | 61/F | 32/M | 58/M |
Prior HSCT | Yes | No | No | Yes | No | No | Yes | No | Yes |
Histology review | DLBCL | Othera | DLBCL | DLBCL | DLBCL | tMALT lymphoma | DLBCL | DLBCL | DLBCL |
Cell of originb | ABC | NA | ABC | ABC | GCB | ABC | GCB | ABC | ABC |
Previous lines of therapies | 4 | 2 | 3 | 2 | 3 | 5 | 2 | 2 | 3 |
Disease status at the start of the trial | Relapsed | Relapsed | Relapsed | Relapsed | Relapsed | Refractory | Relapsed | Relapsed | Refractory |
Double/triple hits | Negative | NA | Negative | Negative | Negative | Negative | Negative | MYC + BCL6 + rearrangements | NA |
Bridging chemotherapy prior to infusion | Yes | Yes | No | No | Yes | Yes | Yes | Yes | No |
Investigator-assessed overall response prior to infusion | CR | SD | PD | PD | SD | PR | SD | PD | SD |
LDH (U/L) prior to infusionc | 144 | 331 H | 222 | 264 H | 497 H | 202 | 261 H | 510 H | 354 H |
ABC activated B cell, DLBCL diffuse large B-cell lymphoma, F female, GCB germinal center B cell, HSCT hematopoietic stem cell transplant, LDH lactate dehydrogenase, M male, NA not available, tMALT transformed mucosa-associated lymphoid tissue
aNeuroendocrine carcinoma
bChoi and modified Choi algorithms and Tally method
cH denotes a value above the upper limit of normal