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. 2020 May 9;26(9):1353–1367. doi: 10.1093/ibd/izaa064

FIGURE 2.

FIGURE 2.

Muc5ac deficiency is detrimental in experimental colitis. Administered DSS (3%) or water to Muc5ac-deficient mice (Muc5ac-/-) and their wildtype control mice (Muc5ac+/+). A, Daily weight measurements displayed as percentage of body weight at day 0. B, On day 7, post-DSS colons harvested and measured. C, Representative histological sections from colon harvested at day 7 post-DSS (bar represents 200 µm; images acquired at 10x). D, Histological analysis of whole colon (proximal and distal combined scores) harvested at day 7 post-DSS provided by pathologist blinded to the groups and the study. Results representative of at least 3 independently performed experiments and displayed as mean ± SEM; n = 5 mice/water group, n = 11 to 17 mice/DSS group. Two-way ANOVA with posthoc Bonferroni t test used to determine statistical weight change; in all other cases unpaired Student t test used. ANOVA indicates analysis of variance. SEM indicates standard error of the mean. *P< 0.05.