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. 2020 May 9;26(9):1353–1367. doi: 10.1093/ibd/izaa064

FIGURE 6.

FIGURE 6.

Colonic mucosal microbiome is altered in Muc5ac-deficient (Muc5ac-/-) and wildtype (Muc5ac+/+) mice during experimental colitis. Administered DSS (3%) or water to Muc5ac-/- and Muc5ac+/+ littermates generated by a heterozygous breeding strategy. On day 6, DSS replaced with normal drinking water. Mice sacrificed after 3 days of normal drinking water (day 9) and whole colon excised. Extracted DNA from the colonic mucosal lining and performed 16S rRNA gene sequencing to profile bacterial taxa in each group. Colored bars represent relative abundance (%) of particular taxa averaged in each group. Data represent >3 independent experiments; n = 8 mice/group. Statistical differences calculated using nonparametric permutation-based multiple analysis of variance tests. *P< 0.05.