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. 2020 Aug 20;10:14025. doi: 10.1038/s41598-020-70860-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibitory effect of dihydroartemisinin on P. falciparum 3D7 cultures as detected by RMOD assay. A MO values as a function of incubation time at 1% parasitemia incubated with various concentrations of dihydroartemisinin. The top axis shows the age of the parasites at the given sampling points, determined by optical microscopic evaluation. Below the graph, an image shows the typical parasite stage at the starting point of the assay. The color coding of the curves indicates the increasing drug concentrations from light to dark shades. The empty circles represent the growth of drug-free control samples. Each circle represents the average of the MO values measured on triplicates. B IC50 values of the dihydroartemisinin assay as a function of incubation time. The calculated values show a systematic increase during the complete intraerythrocytic cycle. The blue shaded area indicates the range of IC50 values reported earlier (Supplementary Table S1)^30–33. The upper right corner shows a representative dose–response fit curve corresponding to the 32 h time point of the 1% assay.