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. 2020 Aug 20;10:14039. doi: 10.1038/s41598-020-70032-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relation of TCs with immune cells. (A) sub-epithelial TCS (T, blue color) and (B) TCS (T, blue color) in the lamina propria established a 3D network that connected with macrophages, (mc, turquoise color, double arrowhead), mast cells (m, brown color, arrowhead), and smooth muscle fibers (SMF, reddish brown, arrow). Note: epithelium (EP, gray color). (C) TCS (T, blue color) in the lamina propria connected with dendritic cells (d, violet color), macrophage (mc, double arrowhead), and smooth muscle fibers (SMF, reddish-brown) .(D–F) Tcs (T, blue color) connected with Schwann cell (sh, dark green color, blue double black arrowheads), nerve fibers (n, blue arrow), lymphocyte (L. blue double arrow), and dendritic cells (violet color, double arrow). Note mast cells (brown color, m), smooth muscle fibers (reddish-brown color, SMF), fibroblast (f).