Table 2.
Previous Studies Analyzing the Dynamics of Corneal Wound Healing
| Reference | Species | Wound Details |
|---|---|---|
| Hou et al., 2020 43 | C57BL/6J mice | 2.5-mm diameter scraped using a blade |
| Okada et al., 2020 44 | Compound transgenic mice | 2-mm diameter using microsurgical blade |
| Murataeva et al., 2019 45 | C57BL/6J and CD1 mice | ∼1-mm diameter using an Alger Brush |
| Park et al. 2019 19 | K14CreER-Confetti mice | 2-mm diameter using Algerbrush with 1-mm burr |
| Nasser et al., 2018 9 | K15-GFP/Confetti mice | Limbal removal with Algerbrush |
| Chen et al., 2017 46 | Male C57BL/6 mice | 3-mm diameter using Algerbrush II |
| Zhang et al., 2017 47 | Female C57BL/6 mice | 2-mm diameter trephine and golf club spud |
| Huang et al., 2017 48 | Sprague-Dawley rats | 4-mm diameter using Algerbrush II with 0.5-mm burr |
| Walczysko et al., 2016 49 | Transgenic mice on the CBA/Ca genetic background | 1-mm diameter scraped using scalpel blade |
| Rush et al., 2016 50 | Female C57BL6/J mice | 1.5-mm diameter using Algerbrush II with 0.5-mm burr |
| Amitai-Lange et al., 2015 8 | R26R-Confetti mice | DMSO injury |
| Martin et al., 2013 51 | Wistar male adult rats | 1-mm diameter cauterization with silver nitrate sticks |
| Kawakita et al. 2011 39 | Japanese white rabbit | 4-, 5-, 6-, and 8-mm diameter |
| Yang et al., 2010 52 | Female NZ white rabbits | 6-mm diameter using No. 15 scalpel blade |
| de Faria-e-Sousa et al., 2010 40 | NZ white rabbit | Epithelium scraped outside central 6- mm diameter with ophthalmic spatula |
| Majo et al., 2008 13 | Wild-type, OF1, Athymic and SCID mice | 1.5 mm × 0.3 mm of the limbus of athymic mice were excised and transplanted with 1.5-mm diameter wound using spatula |
| Li et al., 2004 53 | Male C57BL/6 mice | 2-mm diameter trephine and diamond blade for refractive surgery (Accutome) |
| Danjo and Gipson 2002 17 | Male Balb/c mice 6-9 weeks | 2.0- or 2.5-mm diameter corneal epithelium debrided with a blunted blade, leaving the basement membrane intact |
| Huang and Tseng, 1991 38 | NZ white rabbit | 7.5-mm trephine and surgical blade used twice |
| Crosson et al., 1986 54 | NZ white rabbit | 2-, 4-, or 6-mm diameter |
| Buck RC. 1979 14 | Male or female Swiss mice | Small circular 1.0- to 1.4-mm diameter or large ∼3-mm diameter irregular or elongated wounds of denuded epithelium by repeatedly pressing against the proptosed eye using a microscope slide previously coated with 10% gelatin solution and allowed to dry |
| Kuwabara et al., 1976 16 | NZ albino rabbits | Linear stromal wound 5 mm long and 0.2 mm deep |
| Hanna C. 1966 15 | Adult albino rabbits and rats | 1 mm wide and 5 mm long, 1.5 mm from limbus |