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. 2020 Aug 11;61(10):20. doi: 10.1167/iovs.61.10.20

Figure 1.

Figure 1.

CNTF affects angiogenesis in the eye. (A) Representative flatmounts and quantification of NV tufts in Vldlr–/– mice at P18 following intravitreal treatment with 500 ng CNTF or 5 ng CNTF at P12. n (500 ng) = 16 mice, n (5 ng) = 15 mice, two-sided Student's t-test: *P < 0.05. (B) Representative flatmounts and quantification of intraretinal NV in Vldlr–/– mice at P34 following intravitreal injections of 500 ng CNTF at P12 or P19. n (P34 inj P12) = 21 mice, n (P34 inj P19) = 11 mice, two-sided Student's t-test: *P < 0.05. (C) Representative images and quantified area of CNV lesions 7 days after laser injury following intravitreal injections of 500 ng or 5 ng CNTF 1 day after laser treatment. n (500 ng) = 10 retinas, n (5 ng) = 13 retinas, two-sided Student's t-test: *P < 0.05. (D) Representative flatmounts and quantification of deep vascular plexus formation by the number of junctions at P12 following CNTF treatment (500 ng) at P7. n = 6 mice, two-sided Student's t-test: *P < 0.05.