Effects of TRIM59 on the cell-cycle distribution. (A, B) G1 phase arrest in HXO-Rb44 cells induced by TRIM59 expression downregulation was detected by flow cytometry. **P < 0.01 compared with the siNC group. (C, D) TRIM59 significantly promoted the G1/S phase transition in Y79 cells **P < 0.01 compared with vector-transfected cells. The cell-cycle-related protein cyclin D1 was detected in HXO-Rb44 cells (E, F) and Y79 cells (G, H) by immunoblotting. **P < 0.01 compared with the siNC and vector groups, respectively.