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. 2020 Aug 3;61(10):2. doi: 10.1167/iovs.61.10.2

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Figure 6. — TRIM59 promotes retinoblastoma tumor growth in a xenograft model. (A, B) Representative images of subcutaneous tumors in mice receiving siTRIM59 or the negative control (siNC). (C) Quantification of tumor weight. ^*P < 0.05 compared with the siNC group. (D)Tumor growth curves comparing the group of mice receiving siTRIM59 with the control group. ^*P < 0.05 compared with the siNC group. (E) TRIM59 knockdown confirmed by immunohistochemical staining. Magnification, 200×. (F, G) Immunoblotting results indicating that, compared with control treatment, silencing TRIM59 led to reduced expression of TRIM59, cyclin D1, and Bcl-2 and increased expression of cleaved caspase-3. ^**P < 0.01 compared with the siNC group.