Figure 8.

p38 inhibition alleviates TRIM59-mediated retinoblastoma progression. The p38-specific inhibitor SB203580 effectively suppressed cell proliferation (A, B) and the G₁/S phase transition (C, D) and promoted cell apoptosis (E, F) in TRIM59-overexpressing Y79 cells using the methods described above. ^**P < 0.01, “SB203580 + oeTRIM59” group compared with “vehicle + oeTRIM59” group; ^††P < 0.01, “SB203580 + vector” group compared with “vehicle + vector” group. (G, H) Immunoblotting was performed to evaluate the expression of p-p38, cyclin D1, Bcl-2, and cleaved caspase-3. ^*P < 0.05, ^**P < 0.01, “SB203580 + oeTRIM59” group compared with “vehicle + oeTRIM59” group; ^††P < 0.01, “SB203580 + vector” group compared with “vehicle + vector” group.