Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation and function of miR-222/VHL/HIF1α axis in chemoresistance of RB cells. miR-222 downregulated VHL to elevate the expression of HIF1α through inhibition of ubiquitin–proteasome degradation, thereby enhancing RB cell proliferation and attenuating apoptosis, which accelerates RB resistance to VCR.
