Figure 2.

Reduced nerve size in response to microbead injection. Comparing un-injected eyes, Fbn1^Tsk/+ mice had enlarged optic nerves compared to wt (A). Analysis (B) comparing uninjected (left symbols) with bead-injected eyes (right symbols) showed significant reduction in cross-sectional area of nerves from wt (blue symbols) and Fbn1^Tsk/+ mice (red symbols) but not for sham-injected controls (data not shown). Numbers of microbead-injected animals: 43 wt and 29 Fbn1^Tsk/+: sham-injected: 12 wt and 9 Fbn1^Tsk/+. Dashed lines connect paired eyes (B).