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The implications of different blood cells in atherosclerosis pathogenesis. NETs are released on activation of neutrophils by factors such as OX-LDL and cholesterol crystals. NETs stimulate macrophage to produce IL-1β, which stimulates T-helper 17 to secrete IL-17. IL-17 is responsible for recruitment of more immune cells, including dendritic cells, macrophages, and lymphocytes. (A color version of this figure is available in the online journal.)
