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The interplay between neutrophils and platelets. Activated platelets secrete high-mobility group box 1 (HMGB-1) that activate and induce neutrophils to form and release NETs. Consequently, neutrophils produce NE, proteases, and cathepsin-G embedded on NETs, which in turn activate more platelets in a reciprocal process. (A color version of this figure is available in the online journal.)
