Table 2.

SNPs Showing Significant Associations With STDR/PDR

						MAF
Phenotype	Nearest Gene(s)	SNP	Position	A1	A2	Non-STDR	STDR	OR (95% CI)	P Value*	q-Value§
STDR	COL5A1	rs59126004‡	9:137674341	C	T	0.17	0.14	0.84 (0.71–0.98)	0.034	0.798
	IGSF21-KLHDC7A	rs3007729	1:18795255	T	C	0.32	0.30	0.87 (0.77–0.99)	0.034	0.798
	CREB5	rs11765845	7:28391142	A	G	0.29	0.28	0.87 (0.76–0.99)	0.036	0.798
	LOC728275-LOC728316	rs227455†	6:165478051	C	T	0.48	0.47	0.89 (0.79–0.99)	0.048	0.798
PDR	INSR	rs2115386†	19:7196565	C	T	0.47	0.52	1.25 (1.06–1.47)	5.65 × 10−3	0.190
	UBE2E2	rs79941515‡	3:23225738	T	C	0.18	0.14	0.72 (0.57–0.91)	6.75 × 10−3	0.190
	MYT1L-LOC729897	rs10199521†	2:2519513	T	C	0.35	0.39	1.24 (1.05–1.47)	8.93 × 10−3	0.190
	COL5A1	rs59126004‡	9:137674341	C	T	0.17	0.13	0.73 (0.57–0.93)	0.011	0.190
	ZNRF1	rs17684886†	16:75086875	A	T	0.47	0.43	0.82 (0.69–0.97)	0.022	0.259
	IGSF21-KLHDC7A	rs3007729	1:18795255	T	C	0.32	0.29	0.81 (0.67–0.97)	0.023	0.259
	AKAP11-FABP3P2	rs117850847	13:42909215	A	C	0.06	0.04	0.65 (0.44–0.96)	0.030	0.259
	CCDC68-TCF4	rs12607567†	18:52858659	G	A	0.47	0.44	0.83 (0.70–0.98)	0.030	0.259

A1, minor allele; A2, major allele; MAF, minor allele frequency.

SNPs are ranked by P value. Chromosomal position corresponds with human reference genome hg19. OR corresponds with the minor allele.

^*Adjusted for age, sex, BMI, duration of diabetes, the presence of HTN, and HbA1c.

^§Independent FDR correction for each test.

^†Direction of effect consistent with original report.

^‡Direction of effect not available in original report.