Table 3.

Significant Findings in Interaction Analysis of SNP × Dichotomized HbA1c for STDR/PDR

STDR
				HbA1c <7% (case/control = 328/962)			HbA1c ≥7% (case/control = 723/1,080)
Nearest Gene(s)	SNP	A1	A2	OR (95% CI)	P -Value*	q-Value§	OR (95% CI)	P -Value*	q-Value§	P interaction *	q-Value§
COL5A1	rs59126004	C	T	0.58 (0.44–0.77)	1.76 × 10−4	7.04 x10−4	1.01 (0.83–1.23)	0.893	0.893	1.73 × 10−3	6.92 × 10−3
CREB5	rs11765845	A	G	0.82 (0.66–1.01)	0.069	0.092	0.90 (0.77–1.06)	0.219	0.292	0.433	0.633
IGSF21-KLHDC7A	rs3007729	T	C	0.81 (0.66–1.00)	0.056	0.092	0.89 (0.76–1.04)	0.143	0.286	0.523	0.633
LOC728275-LOC728316	rs227455	C	T	0.92 (0.76–1.12)	0.434	0.434	0.86 (0.75–0.99)	0.047	0.188	0.633	0.633
PDR
				HbA1c <7% (case/control = 121/962)			HbA1c ≥7% (case/control = 288/1080)
Nearest Gene(s)	SNP	A1	A2	OR (95% CI)	P -Value *	q-Value §	OR (95% CI)	P -Value *	q-Value §	Pinteraction *	q-Value §
COL5A1	rs59126004	C	T	0.37 (0.22–0.60)	8.35 × 10−5	6.68 × 10−4	0.95 (0.72–1.25)	0.727	0.727	1.73 × 10−3	0.014
MYT1L-LOC729897	rs10199521	T	C	1.13 (0.84–1.51)	0.397	0.454	1.32 (1.08–1.62)	6.51 × 10−3	0.036	0.392	0.843
CCDC68-TCF4	rs12607567	G	A	0.93 (0.70–1.23)	0.619	0.619	0.81 (0.67–0.99)	0.047	0.075	0.478	0.843
INSR	rs2115386	C	T	1.17 (0.89–1.55)	0.241	0.386	1.3 (1.06–1.58)	9.03 × 10−3	0.036	0.519	0.843
IGSF21-KLHDC7A	rs3007729	T	C	0.85 (0.62–1.15)	0.297	0.396	0.77 (0.62–0.96)	0.023	0.046	0.527	0.843
ZNRF1	rs17684886	A	T	0.81 (0.60–1.09)	0.172	0.386	0.84 (0.69–1.02)	0.086	0.098	0.764	0.979
UBE2E2	rs79941515	T	C	0.71 (0.48–1.05)	0.094	0.376	0.71 (0.53–0.94)	0.020	0.046	0.967	0.979
AKAP11-FABP3P2	rs117850847	A	C	0.64 (0.31–1.32)	0.233	0.386	0.67 (0.43–1.05)	0.085	0.098	0.979	0.979

A1, minor allele; A2, major allele; MAF, minor allele frequency.

SNPs are ranked by P_interaction. Chromosomal position corresponds with human reference genome hg19. OR corresponds with the minor allele.

^*Adjusted for age, sex, BMI, duration of diabetes and the presence of HTN.

^§Independent FDR correction for each test.