| 1 |
CLCA4 |
Chloride channel accessory 4 |
May be involved in mediating calcium-activated chloride conductance |
| 2 |
GUCA2A |
Guanylate cyclase activator 2A |
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins |
| 3 |
GCG |
Glucagon |
Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-1 is a potent stimulator of glucose-dependent insulin release. GLP-2 stimulates intestinal growth, concomitant with increased crypt cell proliferation |
| 4 |
SST |
Somatostatin |
Somatostatin inhibits the release of somatotropin. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract |
| 5 |
MS4A12 |
Membrane spanning 4-domains A12 |
May be involved in signal transduction as a component of a multimeric receptor complex. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells |
| 6 |
PLP1 |
Proteolipid protein 1 |
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin |
| 7 |
CHGA |
Chromogranin A |
This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin |
| 8 |
PYY |
Peptide YY |
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action, and inhibitis jejunal and colonic mobility |
| 9 |
VIP |
Vasoactive intestinal peptide |
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gallbladder |
| 10 |
GUCA2B |
Guanylate cyclase activator 2B |
May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport |
