Table.
Results of 18 Studies Assessing the Difference in Mean Thickness (in Microns) of the Peripapillary Retinal Nerve Fiber Layer in Eyes of Healthy Control Patients and in Eyes of Patients With MS Without Optic Neuritis
| MS without Optic Neuritis | Healthy Controls | Difference | 95% Confidence Interval | Fixed-Effects | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studies | Eyes | Mean | SD | Eyes | Mean | SD | Mean = y | SE | Lower Bound | Upper Bound | t-Ratio | P Value | Weights | |
| Balk (2014) | 279 | 85.5 | 10.1 | 126 | 91.7 | 6.8 | −6.2 | 0.86 | −7.88 | −4.52 | −7.24 | 0.000 | 1.365 | 0.195 |
| Behbehani (2015) | 72 | 102.7 | 11.5 | 51 | 111.3 | 8.7 | −8.6 | 1.82 | −12.17 | −5.03 | −4.72 | 0.000 | 0.301 | 0.043 |
| Behbehani (2016) | 10 | 89 | 16.2 | 40 | 94.9 | 6 | −5.9 | 5.21 | −16.11 | 4.31 | −1.13 | 0.257 | 0.037 | 0.005 |
| Esen (2016) | 54 | 89.2 | 11.2 | 60 | 96.7 | 8.2 | −7.5 | 1.86 | −11.14 | −3.86 | −4.04 | 0.000 | 0.290 | 0.042 |
| Feng (2013) | 12 | 92 | 8.5 | 28 | 102.1 | 8.1 | −10.1 | 2.89 | −15.77 | −4.43 | −3.49 | 0.000 | 0.120 | 0.017 |
| Gelfand (2012) | 820 | 91.5 | 13.7 | 106 | 101.3 | 10.1 | −9.8 | 1.09 | −11.94 | −7.66 | −8.98 | 0.000 | 0.839 | 0.120 |
| Gonzalez–Lopez (2014) | 104 | 90.7 | 12.7 | 140 | 99.3 | 8.7 | −8.6 | 1.45 | −11.43 | −5.77 | −5.95 | 0.000 | 0.478 | 0.068 |
| Huang–Link (2015) | 15 | 87.7 | 9.7 | 68 | 93.6 | 8.9 | −5.9 | 2.73 | −11.25 | −0.55 | −2.16 | 0.031 | 0.134 | 0.019 |
| Khalil (2016) | 38 | 92.4 | 17.7 | 23 | 117.8 | 26.2 | −25.4 | 6.17 | −37.50 | −13.30 | −4.12 | 0.000 | 0.026 | 0.004 |
| Klistorner (2014) | 53 | 94 | 6.5 | 50 | 99 | 9.8 | −5 | 1.65 | −8.23 | −1.77 | −3.03 | 0.002 | 0.368 | 0.053 |
| Knier (2016) | 36 | 97 | 10.4 | 38 | 100.1 | 8.6 | −3.1 | 2.23 | −7.46 | 1.26 | −1.39 | 0.164 | 0.202 | 0.029 |
| Lange (2013) | 37 | 93.2 | 14.4 | 100 | 98.4 | 8.8 | −5.2 | 2.53 | −10.15 | −0.25 | −2.06 | 0.040 | 0.157 | 0.022 |
| Oberwahrenbrock (2012) | 571 | 90.2 | 12.3 | 183 | 100.6 | 9.4 | −10.4 | 0.86 | −12.09 | −8.71 | −12.03 | 0.000 | 1.337 | 0.191 |
| Oberwahrenbrock (2013) | 66 | 99.9 | 11.3 | 66 | 100.7 | 8 | −0.8 | 1.70 | −4.14 | 2.54 | −0.47 | 0.639 | 0.344 | 0.049 |
| Petracca (2016) | 50 | 86.9 | 13.6 | 40 | 92.8 | 12.4 | −5.9 | 2.75 | −11.28 | −0.52 | −2.15 | 0.032 | 0.133 | 0.019 |
| Soufi (2015) | 55 | 91 | 11 | 58 | 104 | 8.7 | −13 | 1.87 | −16.67 | −9.33 | −6.94 | 0.000 | 0.285 | 0.041 |
| Walter (2012) | 150 | 87.6 | 11.1 | 61 | 92.9 | 9.9 | −5.3 | 1.56 | −8.35 | −2.25 | −3.40 | 0.001 | 0.412 | 0.059 |
| Xu (2016) | 41 | 89.3 | 11.5 | 41 | 97.1 | 11.5 | −7.8 | 2.54 | −12.78 | −2.82 | −3.07 | 0.002 | 0.155 | 0.022 |
SD, standard deviation.