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. 2020 Aug 12;61(10):25. doi: 10.1167/iovs.61.10.25

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Figure 8. — Effect of MMF on whole retinal cGMP levels in rd10 and rd1 mice. Whole retinal levels of cGMP quantified by LC-MS show that in c57 mice, there was a gradual rise that plateaued by P27. Naïve rd1 mice had cGMP levels significantly greater than c57 mice at P13 (n = 4 and 5, P = 0.0024), P15 (n = 17 and 11, P < 0.0001), and P17 (n = 3 and 4, P = 0.0136), whereas rd10 mice had cGMP levels that trended lower than c57 from P15 to P19 and were significantly lower than c57 mice at P22 (n = 14 and 13, P < 0.0001), P27 (n = 8 and 9, P = 0.0002), and P35 (n = 9 and 10, P < 0.0001). The cGMP levels in rd1 mice were significantly greater than rd10 mice at P12 (n = 3 and 6, P < 0.0001), P15 (n = 17 and 13, P < 0.0001), and P17 (n = 3 and 5, P = 0.008). Naïve rd10 mice exhibited a relative spike in cGMP levels at P19, which appeared to be delayed until P27 in rd10 mice treated with MMF beginning at P12 (MMFP12). However, for each time point, cGMP levels were not significantly different between naïve and MMFP12-treated rd10 mice at P22 (n = 13, P = 0.70), P27 (n = 6, P = 0.08), and P35 (n = 6, P = 0.26). Compared with naïve rd1 mice, the cGMP levels were also not significantly different in MMFP8-treated rd1 mice at P15 (n = 7, P = 0.32). ns, nonsignificant; ^*P ≤ 0.05.