Table 2.

Detailed Results of the Longitudinal Retinal Thickness Changes^*

		Follow Up 1				Follow Up 2				Follow Up 3
Retinal Thickness	Area	Estimates (in SD)	SE (in SD)	P Value	Estimates as Thickness Deviation (in µm)	Estimates (in SD)	SE (in SD)	P Value	Estimates as Thickness Deviation (in µm)	Estimates (in SD)	SE (in SD)	P Value	Estimates as Thickness Deviation (in µm)
Total Retina	RPD	−0.258	0.09	P = 0.011	−4.8	−0.553	0.09	P < 0.001	−10.4	−0.519	0.09	P < 0.001	−9.7
	New RPD	−0.140	0.12	P = 0.254	−2.6	−0.262	0.12	P = 0.036	−4.9	−0.267	0.12	P = 0.029	−5.0
	Non-RPD	0.282	0.11	P = 0.124	5.3	−0.044	0.11	P = 0.683	−0.8	−0.067	0.11	P = 0.535	−1.3
Inner Retina	RPD	−0.171	0.07	P = 0.029	−3.2	−0.289	0.08	P = 0.001	−5.4	−0.175	0.08	P = 0.040	−3.3
	New RPD	−0.050	0.11	P = 0.653	−0.9	−0.130	0.11	P = 0.248	−2.4	−0.242	0.10	P = 0.029	−4.5
	Non-RPD	0.337	0.09	P = 0.001	6.3	0.111	0.09	P = 0.239	2.1	0.004	0.09	P = 0.964	0.1
RPED-Complex	RPD	−0.384	0.18	P = 0.049	−7.2	−0.470	0.19	P = 0.022	−8.8	−0.276	0.19	P = 0.165	−5.2
	New RPD	0.230	0.24	P = 0.339	4.3	0.304	0.24	P = 0.209	5.7	0.637	0.23	P = 0.009	12.0
	Non-RPD	0.188	0.21	P = 0.378	3.5	0.150	0.21	P = 0.483	2.8	0.096	0.21	P = 0.653	1.8
pORL	RPD	−0.104	0.06	P = 0.118	−2.0	−0.479	0.07	P < 0.001	−9.0	−0.668	0.07	P < 0.001	−12.5
	New RPD	−0.282	0.10	P = 0.005	−5.3	−0.431	0.10	P < 0.001	−8.1	−0.404	0.09	P < 0.001	−7.6
	Non-RPD	−0.024	0.08	P = 0.773	−0.5	−0.313	0.08	P < 0.001	−5.9	−0.173	0.08	P = 0.041	−3.2

^*The z-scores (estimate ± SE) in SD of the control group at each follow-up visit (FU 1, FU 2, FU 3) in regions with RPD, new arising regions of RPD (New RPD), and unremarkable regions of RPD (Non-RPD) with the corresponding longitudinal P values (FU visit to baseline visit). For comparison we provided the estimates in terms of thickness deviation from the spatially corresponding normative value. However, compared to z-scores, these do not take into account for the normative variability in thickness varies across the retina.