Table 4.

Clinical winners (highest value of n4) per model and disease target x considering the 3 domain experts.

Disease target x	Model	NER max (n2)	NER max (n3)	Treatment z1 search query	Treatment z2 search query	n1	n2	n3	n4
heart_failure	CBOWa	—	Yes	cardiac_resynchronization_therapy_(CRT)	aldosterone_antagonists	2	10	9	6
heart_failure	Skip-gram	Yes	Yes	beta-blockers	aldosterone_antagonists	2	12	8	5
glaucoma	CBOW	Yes	Yes	trabeculectomy	cataract_surgery	2	5	5	3
glaucoma	Skip-gram	Yes	Yes	trabeculectomy	cataract_surgery	2	10	6	3
CKDb	CBOW	Yes	Yes	not_requiring_dialysis	dialysis	1	9	7	5
CKD	Skip-gram	Yes	Yes	not_requiring_dialysis	dialysis	1	8	5	5
diabetes	CBOW	Yes	Yes	glucose_variability	glucagon-like_peptide-1_receptor_agonists	2	10	6	6
diabetes	Skip-gram	Yes	Yes	glucose_variability	glucagon-like_peptide-1_receptor_agonists	2	10	5	4
asthma	CBOW	—	Yes	inhaled_corticosteroids	inhaled_corticosteroid	1	10	8	8
asthma	Skip-gram	—	—	inhaled_corticosteroids	inhaled_corticosteroid	1	11	8	7
epilepsy	CBOW	—	—	valproate	antiepileptic_drug	2	11	10	8
epilepsy	CBOW	—	—	valproate	antiepileptic_drugs	2	11	10	8
epilepsyc	Skip-gram	Yes	Yes	valproate	AEDd	2	12	11	7
arthritis	CBOW	Yes	Yes	plus_methotrexate	methotrexate	1	12	9	2
arthritisc	Skip-gram	—	—	plus_methotrexate	methotrexate	1	7	4	2
osteoarthritis	CBOW	Yes	—	knee_arthroplasty	hyaluronic_acid	2	9	7	5
osteoarthritis	Skip-gram	—	—	vs_acetaminophen	viscosupplementation	2	7	8	7
anaemia	CBOW	Yes	Yes	iron	erythropoiesis-stimulating_agents	2	11	9	4
anaemia	Skip-gram	—	Yes	recombinant_human_erythropoietin	iron	2	11	8	5
hypertension	CBOW	—	Yes	antihypertensive_therapy	antihypertensive	2	11	8	6
hypertension	Skip-gram	Yes	Yes	antihypertensive_drug_classes	antihypertensive	1	12	10	8

^aCBOW: Continuous Bag-of-Words.

^bCKD: chronic kidney disease.

^cNot clinical winners according to O2.

^dAED: antiepileptic drug.