Table 6.
Illustration of a Best clinical winner with max (n4)=8 for CBOW and disease target x = epilepsy, which is not an NER winner.
| Ranka | Candidate y | 3CosAdd | UMLS CUI for concept YTx mapped to candidate yTx | Evidence-based categories for concept YTx correlated with concept X |
| 1 | lamotrigine | 0.385201 | C0064636 | Tx with therapeutic effect |
| 2 | carbamazepine | 0.345227 | C0006949 | Tx with unwanted or adverse effects (ie, nontherapeutic) |
| 3 | low_propensity | 0.324285 | —b | — |
| 4 | clonazepam | 0.310706 | C0009011 | Tx with uncertain therapeutic effect |
| 5 | topiramate | 0.308402 | C0076829 | Tx with therapeutic effect |
| 6 | lithium_valproate | 0.308223 | C0023870|C0080356 | Tx with therapeutic effect|Tx with unwanted or adverse effects (ie, nontherapeutic) |
| 7 | clobazam | 0.306901 | C0055891 | Tx with therapeutic effect |
| 8 | sodium_valproate | 0.300513 | C0037567 | Tx with therapeutic effect |
| 9 | lorazepam | 0.29562 | C0024002 | Tx with therapeutic effect |
| 10 | lithium | 0.294804 | C0023870 | Tx with therapeutic effect|Tx with unwanted or adverse effects (ie nontherapeutic) |
| 11 | gabapentin_pregabalin_topiramate | 0.291698 | C0657912|C0076829|C0060926 | Tx with therapeutic effect |
| 12 | antiepileptic_drugs_other_than | 0.290046 | C0003299 | Tx with therapeutic effect |
aThe search query −x +z1 +z2 is listed in Table 4, which is −epilepsy +valproate +antiepileptic_drug. The character “|” appears when there is more than 1 CUI or evidence-based category.
bThe candidate y = “low_propensity” does not belong to the semantic field Tx, and so, it has no UMLS CUI assigned.