Table 1.
Clinical characteristics of the included studies.
| Surname (year) | Country | Cancer type | Sample size | High | Low | Cutoff (high/low) | Detection method | Clinical features | Quality score | References |
|---|---|---|---|---|---|---|---|---|---|---|
| Fei Tao (2018) | China | Rectal cancer | 152 | 76 | 76 | Median | qRT-PCR | C; T; H | 7 | [19] |
| Guodong Zhang (2019) | China | Osteosarcoma | 60 | 30 | 30 | Median | qRT-PCR | C; L | 6 | [25] |
| Tao Yang (2017) | China | Laryngeal cancer | 65 | 33 | 32 | Median | qRT-PCR | C; L; H | 7 | [17] |
| Zhiliang Lu (2017) | China | NSCLC | 110 | 55 | 55 | Median | qRT-PCR | C; H; T; L | 8 | [26] |
| Wei Huang (2016) | China | TSCC | 96 | 44 | 52 | Mean | qRT-PCR | C; H; T | 7 | [20] |
| Peng Jiang (2019) | China | CRC | 173 | 71 | 102 | Mean | qRT-PCR | C; H; T | 6 | [21] |
| Shun Ke (2018) | China | ESCC | 137 | 68 | 69 | Median | qRT-PCR | C; H | 8 | [16] |
| Ronggao Chen (2020) | China | HCC | 90 | 45 | 45 | Median | qRT-PCR | H | 7 | [24] |
| Xiaolan Yu (2018) | China | HCC | 54 | 27 | 27 | Median | qRT-PCR | NA | 7 | [22] |
NSCLC: non-small-cell lung cancer; TSCC: tongue squamous cell carcinoma; CRC: colorectal cancer; ESCC: esophageal squamous cell carcinoma; HCC: hepatocellular carcinoma; C: clinical stage; H: histological grade; L: lymph node metastasis; T: tumor invasion depth; NA: not available.