Podocyte injury |
In diabetic nephropathy |
Elf3 protein ↑ |
50 pts-5 ctrs |
[48] |
WT1, podocin, Actn4, CD2AP, and nephrin mRNA ↑ |
20 pts-5 ctrs |
[49] |
|
In minimal change nephrotic syndrome |
Podocin, Actn4, CD2AP, and nephrin mRNA ↑ |
|
In metabolic syndrome-related kidney disease |
Podocyte-derived exosomes (nephrin+/podocalyxin+) ↑ |
16 pts-15 ctrs |
[43] |
|
In CKD |
miR-21 ↑ |
41 pts-5 ctrs |
[44] |
|
In cellular crescent formation |
SFP1 ↑ |
37 pts |
[69] |
|
In renovascular hypertension |
Podocyte-derived exosomes (nephrin+/podocalyxin+) ↑ |
31 pts-45 ctrs |
[60] |
|
In lupus nephritis |
miR-29c ↓ |
24 pts-8 ctrs; mice |
[75] |
|
In IgA nephropathy |
|
In focal segmental glomerulosclerosis |
WT-1 ↑ |
25 pts-5 ctrs |
[68] |
|
Proximal tubular injury |
In decompensated cirrhosis |
Maltase glucoamylase ↑ |
24 pts |
[63] |
|
Renal fibrosis |
In CKD |
Nonproximal tubule-derived miR-200b ↑ |
38 pts |
[45] |
miR-29c ↓ |
32 pts-7 and ctrs |
[46] |
CD2AP mRNA ↓ |
32 pts-7 ctrs |
[47] |
|
In lupus nephritis |
miR-29c ↓ |
47pts-20 ctrs |
[82] |
|
Peritubular capillary loss |
In hypertension |
Endothelial-derived EVs (PL-VAP+/CD31+/CD144+) ↑ |
38 pts-14 ctrs |
[59] |
|
Mitochondrial dysfunction |
In diabetic nephropathy |
12 mitochondria-specific metabolites ↓ |
149 pts-23 ctrs |
[50] |