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. 2020 Aug 12;2020:8897833. doi: 10.1155/2020/8897833

Table 4.

Urinary exosomal biomarkers associated with injury localized to a specific cellular or subcellular component of the nephron patients (pts)/control (ctr).

Condition Potential exosomal biomarker Study subjects Reference
Podocyte injury In diabetic nephropathy Elf3 protein ↑ 50 pts-5 ctrs [48]
WT1, podocin, Actn4, CD2AP, and nephrin mRNA ↑ 20 pts-5 ctrs [49]
In minimal change nephrotic syndrome Podocin, Actn4, CD2AP, and nephrin mRNA ↑
In metabolic syndrome-related kidney disease Podocyte-derived exosomes (nephrin+/podocalyxin+) ↑ 16 pts-15 ctrs [43]
In CKD miR-21 ↑ 41 pts-5 ctrs [44]
In cellular crescent formation SFP1 ↑ 37 pts [69]
In renovascular hypertension Podocyte-derived exosomes (nephrin+/podocalyxin+) ↑ 31 pts-45 ctrs [60]
In lupus nephritis miR-29c ↓ 24 pts-8 ctrs; mice [75]
In IgA nephropathy
In focal segmental glomerulosclerosis WT-1 ↑ 25 pts-5 ctrs [68]

Proximal tubular injury In decompensated cirrhosis Maltase glucoamylase ↑ 24 pts [63]

Renal fibrosis In CKD Nonproximal tubule-derived miR-200b ↑ 38 pts [45]
miR-29c ↓ 32 pts-7 and ctrs [46]
CD2AP mRNA ↓ 32 pts-7 ctrs [47]
In lupus nephritis miR-29c ↓ 47pts-20 ctrs [82]

Peritubular capillary loss In hypertension Endothelial-derived EVs (PL-VAP+/CD31+/CD144+) ↑ 38 pts-14 ctrs [59]

Mitochondrial dysfunction In diabetic nephropathy 12 mitochondria-specific metabolites ↓ 149 pts-23 ctrs [50]