Table 2.
Downregulated DAPs in AAD patients (n = 100).
| Accession | Expression of healthy donor | Mean expression of AAD patients (n = 5) | log2FC | Description |
|---|---|---|---|---|
| H3BQZ7 | 2286.5 | 69.33333333 | -5.04344799 | HCG2044799 |
| Q6GMX6 | 24204.11 | 1024.248 | -4.56261507 | IGH@ protein |
| Q6MZQ6 | 21830.2 | 939.36 | -4.53850338 | Putative uncharacterized protein DKFZp686G11190 |
| Q6N089 | 19877.09 | 909.564 | -4.4497876 | Putative uncharacterized protein DKFZp686P15220 |
| V9HW68 | 19889.09 | 1004.376 | -4.3076059 | Epididymis luminal protein 214 |
| Q92626 | 2750 | 187.25 | -3.87639399 | Peroxidasin homolog |
| A0A024R971 | 5098 | 368.058 | -3.79192634 | Fibromodulin, isoform CRA_a |
| A0A087X2C0 | 5633 | 410.31 | -3.77911725 | Ig mu chain C region |
| A0A024R9G4 | 1679 | 122.6666667 | -3.77478706 | Family with sequence similarity 49, member B, isoform CRA_a |
| A0A0G2JPD4 | 6460.29 | 505.912 | -3.67464056 | Uncharacterized protein |
| B0YJ88 | 4307 | 350.696 | -3.61839044 | Radixin |
| Q96C32 | 9160.43 | 752.5633333 | -3.60553042 | Polyubiquitin-C |
| A8K3Q7 | 19376 | 1632.302 | -3.56929086 | Annexin |
| P43652 | 2496.5 | 211.875 | -3.55862163 | Afamin |
| A0A024R0S6 | 5116.29 | 460.624 | -3.47343655 | EH-domain containing 2, isoform CRA_a |
| Q9NZU5 | 5750 | 529.346 | -3.44127902 | LIM and cysteine-rich domains protein 1 |
| F2ZC06 | 3779.75 | 349.452 | -3.43512461 | Thyroid hormone receptor interacting protein 6 isoform 1 |
| P26006 | 4296 | 414.25 | -3.37442039 | Integrin alpha 3/beta 1 |
| A8MX94 | 5754.4 | 581.104 | -3.30779722 | Glutathione S-transferase P |
| B2R6V9 | 1398 | 142 | -3.29940153 | cDNA, FLJ93141, highly similar to Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA |
| P01023 | 3824.29 | 397.764 | -3.26520731 | Alpha 2-macroglobulin |
| O94832 | 1636 | 170.944 | -3.25857706 | Unconventional myosin-Id |
| B4DKT9 | 4013 | 422.1666667 | -3.24879658 | cDNA FLJ54052, highly similar to alpha 1 catenin (cadherin-associated protein) |
| D6RA82 | 5307.67 | 564.375 | -3.23335269 | Annexin |
| B4DQG5 | 2126.25 | 227.9175 | -3.22172763 | cDNA FLJ54122, highly similar to Cytosol aminopeptidase (EC 3.4.11.1) |
| P12235 | 1117 | 125.3333333 | -3.15578712 | ADP/ATP translocase 1 |
| A0A024QZV0 | 1431 | 160.625 | -3.15525531 | HCG1811539, isoform CRA_b |
| Q6UVK1 | 1875 | 210.564 | -3.15455989 | Chondroitin sulfate proteoglycan 4 |
| A0A0B4J1R6 | 1682.75 | 191.546 | -3.13505805 | Transketolase |
| B4DRV4 | 2956 | 340.5 | -3.11791957 | cDNA FLJ55667, highly similar to secreted protein acidic and rich in cysteine |
| A0A024RC65 | 4177 | 531.732 | -2.97369595 | HCG1991735, isoform CRA_a |
| A0A024RDE1 | 1252 | 161.95 | -2.95061419 | SPARC-like 1 (Mast9, hevin), isoform CRA_a |
| Q8TCD0 | 14216 | 1858.354 | -2.93541833 | Uncharacterized protein |
| A0A024RAC9 | 253 | 34 | -2.89553073 | Zinc finger, UBR1 type 1, isoform CRA_c |
| O76024 | 2314 | 313 | -2.8861543 | Wolframin |
| B4DQX8 | 3990 | 547.875 | -2.86447007 | cDNA FLJ51723, highly similar to DCC-interacting protein 13 alpha (fragment) |
| V9HWK1 | 2754 | 387.9425 | -2.82761382 | Triosephosphate isomerase |
| P49327 | 1231.5 | 174.842 | -2.81629294 | Fatty acid synthase |
| B4DNM8 | 360 | 51.75 | -2.79836614 | cDNA FLJ53395, highly similar to Prolyl 3-hydroxylase 1 (EC 1.14.11.7) |
| A0A087WZW8 | 14216 | 2052.316 | -2.7921908 | Protein IGKV3-11 |
| A0A087WUS7 | 2422 | 354.7 | -2.77152763 | Ig delta chain C region |
| B4E3A8 | 1457 | 216.3333333 | -2.75167299 | cDNA FLJ53963, highly similar to leukocyte elastase inhibitor |
| A8K3B6 | 406 | 60.5 | -2.74647268 | Nonspecific protein-tyrosine kinase |
| S6C4R6 | 12602.88 | 1884.586 | -2.74143392 | IgG L chain |
| A0A087WYL9 | 14216 | 2132.92 | -2.73661383 | Ig kappa chain C region |
| Q6GMX0 | 11199.11 | 1698.368 | -2.72116309 | Uncharacterized protein |
| Q6PJF2 | 9283.64 | 1452.93 | -2.67572538 | IGK@ protein |
| P27824 | 1292.5 | 204.5 | -2.65999153 | Calnexin |
| Q6P5S8 | 14216 | 2252.75 | -2.65775646 | IGK@ protein |
| A0A087X130 | 12702.62 | 2022.842 | -2.65067055 | Ig kappa chain C region |
| A0A087WWT3 | 646 | 104 | -2.63495064 | Serum albumin |
| V9HW34 | 9283.64 | 1502.036 | -2.62777119 | Epididymis luminal protein 213 |
| Q8NCL6 | 2879.25 | 479.72 | -2.58542857 | cDNA FLJ90170 fis, clone MAMMA1000370, highly similar to Ig alpha 1 chain C region |
| Q9NPP6 | 3076.09 | 515.486 | -2.57709256 | Immunoglobulin heavy chain variant (fragment) |
| Q96K68 | 2872.08 | 483.564 | -2.57031719 | cDNA FLJ14473 fis, clone MAMMA1001080, highly similar to Homo sapiens SNC73 protein (SNC73) mRNA |
| B4DEA3 | 218 | 37 | -2.55873096 | cDNA FLJ56531, highly similar to UV excision repair protein RAD23 homolog B |
| Q96CD0 | 228.5 | 41 | -2.47849835 | F-box/LRR-repeat protein 8 |
| V9HWF2 | 1684.5 | 306.8175 | -2.45686775 | Malate dehydrogenase |
| A8K4C8 | 5080 | 925.6666667 | -2.45626382 | 60S ribosomal protein L13 |
| A0A024RDY2 | 860 | 158.994 | -2.43536434 | Tumor protein, translationally controlled 1, isoform CRA_a |
| Q6MZV6 | 2675.38 | 500.17 | -2.41925339 | Putative uncharacterized protein DKFZp686L19235 |
| A0A024RB01 | 2564 | 484.4 | -2.40412549 | Integrin, alpha 5 (fibronectin receptor, alpha polypeptide), isoform CRA_b |
| A6NLN1 | 652 | 123.9175 | -2.39549202 | Polypyrimidine tract binding protein 1, isoform CRA_b |
| P07204 | 989 | 190.33 | -2.37746754 | Thrombomodulin |
| F6U211 | 253 | 49.46666667 | -2.35460879 | 40S ribosomal protein S10 |
| P63267 | 1432 | 283.6666667 | -2.33576296 | Actin, gamma-enteric smooth muscle |
| A0A0C4DFX3 | 829 | 164.6666667 | -2.33182356 | EMILIN-1 |
| A6NNI4 | 571 | 114.3333333 | -2.32024467 | Tetraspanin |
| A0A024RA21 | 843 | 170.8 | -2.30322466 | Secernin 1, isoform CRA_a |
| B2R5H0 | 1174 | 245.915 | -2.25520077 | Protein S100 |
| B4DPU3 | 7412 | 1556.5 | -2.2515573 | cDNA FLJ56548, highly similar to elongation factor 2 |
| Q6MZU6 | 6876.26 | 1445.532 | -2.25002355 | Putative uncharacterized protein DKFZp686C15213 |
| A0A024R1N1 | 1066 | 224.5 | -2.24742009 | Myosin, heavy polypeptide 9, nonmuscle, isoform CRA_a |
| A0A075B6N8 | 6872.24 | 1450.324 | -2.24440519 | Ig gamma-3 chain C region (fragment) |
| B7Z539 | 898 | 192.05 | -2.22523348 | cDNA FLJ56954, highly similar to interalpha trypsin inhibitor heavy chain H1 |
| A0A024R930 | 232 | 49.75 | -2.22135637 | Proteoglycan 4, isoform CRA_a |
| A8K9M5 | 1651.17 | 354.448 | -2.21984277 | cDNA FLJ77947, highly similar to human complement protein C8 beta subunit mRNA |
| A0A024R7Z5 | 412.5 | 89.2075 | -2.20915721 | Syndecan binding protein (Syntenin), isoform CRA_c |
| B4DDS8 | 846 | 184.5 | -2.19703685 | cDNA FLJ56686, moderately similar to FADD protein |
| A0A024R3W7 | 239 | 52.5 | -2.18662129 | Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a |
| A0A087WUN8 | 371 | 82 | -2.17772337 | Syntaxin-binding protein 2 |
| B4DTX5 | 1412 | 314.816 | -2.16515932 | cDNA FLJ60072, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript variant 6, mRNA |
| Q9BVK6 | 267 | 59.75 | -2.15982912 | Transmembrane emp24 domain-containing protein 9 |
| Q9Y217 | 430 | 96.33333333 | -2.15822967 | Myotubularin-related protein 6 |
| Q8IWB1 | 194 | 43.5 | -2.15696935 | Inositol 1,4,5-trisphosphate receptor-interacting protein |
| A0A075B6G3 | 818.5 | 183.5766667 | -2.15659972 | Dystrophin |
| K7EQQ3 | 6367 | 1439.5 | -2.14504598 | Keratin, type I cytoskeletal 9 |
| B4E2F9 | 1999.32 | 455.736 | -2.13323916 | cDNA FLJ57038, highly similar to Filamin-A |
| C9JAK5 | 1520 | 346.7 | -2.13231158 | ADP-ribosylation factor 4 |
| B7Z9B7 | 1412 | 322.75 | -2.12925109 | cDNA FLJ54732, moderately similar to sorbin and SH3 domain-containing protein 1 |
| B2ZZ89 | 884 | 202.512 | -2.12603897 | Epididymis luminal protein 102 |
| A0M8W4 | 902 | 207.5 | -2.1200161 | Ubiquitin-conjugating enzyme E2 variant 2 |
| B0QZ18 | 3015 | 723.296 | -2.05949992 | Copine-1 |
| A0A024RAX0 | 676 | 162.25 | -2.05880477 | Matrix Gla protein |
| B0QY01 | 225 | 54.125 | -2.05555798 | Target of Myb protein 1 (fragment) |
| A0A087WU08 | 2574 | 619.875 | -2.05396283 | Haptoglobin |
| A0A024R6P0 | 2748 | 666.416 | -2.04388706 | Serpin peptidase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3, isoform CRA_c |
| A0A024RD41 | 3012 | 731.6666667 | -2.04146333 | RAB23, member RAS oncogene family, isoform CRA_a |
| A0A024R1Z6 | 242.5 | 59 | -2.03919789 | Vesicle amine transport protein 1 homolog (T. californica), isoform CRA_a |
| Q59EQ1 | 478 | 119.5 | -2 | Cadherin 11, type 2 isoform 1 preproprotein variant (fragment) |
Note: based on protein abundance. A protein was defined as DAPs if there was a log2FC in less of -2.