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. 2020 Aug 20;11(4):e01833-20. doi: 10.1128/mBio.01833-20

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FIG 5 — Thermal stability of M^pro in the presence or absence of GRL-0920. Thermal stability of M^pro in the presence of GRL-0920 was analyzed using differential scanning fluorimetry (DSF) as described for experiment 1. Note that the T_m value of M^pro (5 μM) alone was 53.63°C, while the T_m values decreased to 51.04, 49.13, and 46.98°C in the presence of 5, 50, and 100 μM GRL-0920, respectively, suggesting that the M^pro get destabilized when GRL-0920 covalently bound to M^pro. Note that, as expected, the presence of HIV-1 protease inhibitor GRL-142 (5 μM) increased the thermal stability of HIV-1 protease (5 μM) as shown for experiment 2.