Table 1:
Predictors of favorable outcome after stroke in the CADISP cohort
| Predictor | Outcome | OR | 95%CI | p-value | ||
|---|---|---|---|---|---|---|
| unfavorable (n=122) | favorable (n=694) | univariate | multivariate | |||
| Female sex (n)§ | 40 (32.8) | 297 (42.8) | 1.35 | 0.79–2.36 | 0.046 | 0.279 |
| Age (mean±SD) | 46.4±8.5 | 43.8±10.6 | 0.97 | 0.95–0.99 | 0.002 | 0.040 |
| CeAD etiology (n)§ | 70 (57.4) | 323 (46.5) | 1.11 | 0.65–1.89 | 0.031 | 0.707 |
| NIHSS (median)$ | 14 [0–40] | 2 [0–24] | 0.81 | 0.78–0.84 | <0.001 | <0.001 |
| Imbalance (median/mean) $ | 0/0.94 [0–29] | 0/0.51 [0–28] | 0.89 | 0.82–0.95 | 0.242 | 0.001 |
| Imbalance with ohnologs (median/mean) $ | 0/0.57 [0–29] | 0/0.23 [0–28] | 0.88 | 0.80–0.95 | 0.056 | 0.002 |
| Imbalance without ohnologs (median/mean) $ | 0/0.30 [0–8] | 0/0.25 [0–25] | 0.93 | 0.80–1.18 | 0.942 | 0.42 |
The association between functional outcome and different types of genetic imbalance was assessed by multivariate logistic regression analysis (model 1: continuous genetic imbalance), each time adjusted for age, sex and ancestry-derived principal components 1–10 as potential confounders, and including stroke etiology (CeAD vs non-CeAD) and stroke severity (NIHSS) as additional covariates. CeAD indicates cervical artery dissection; NIHSS, NIH stroke scale; OR, model-adjusted odds ratio of favorable outcome; 95%CI, 95% confidence interval of OR
percentage in brackets
range in square brackets.
Univariate p-values obtained by non-model-based methods: χ2-squared test, Student’s t test or Mann-Whitney U-test, as appropriate.