Table 2:

Predictors of favorable outcome after stroke in the SiGN/GISCOME cohort

Predictor	Outcome		OR	95%CI	p-value
	unfavorable (n=889)	favorable (n=1609)			univariate	multivariate
Female sex (n)§	459 (51.6)	580 (36.0)	8.107	0.75–96.33	<0.001	0.081
Age (mean±SD)	73.7±12.9	64.3±13.7	0.943	0.93–0.95	<0.001	<0.001
TOAST/CCS etiology	n.d.	n.d.	1.01	0.94–1.09	<0.001	0.709
NIHSS (median)$	7 [0–41]	3 [0–30]	0.822	0.80–0.84	<0.001	<0.001
Imbalance (median/mean) $	0/1.18 [0–48]	0/0.90 [0–27]	0.94	0.91–0.98	0.91	0.0036
Imbalance with ohnologs (median/mean) $	0/0.69 [0–48]	0/0.37 [0–27]	0.93	0.89–0.98	0.093	0.002
Imbalance without ohnologs (median/mean) $	0/0.49 [0–14]	0/0.53 [0–13]	0.99	0.92–1.07	0.19	0.89

The association between functional outcome and different types of genetic imbalance was assessed by multivariate logistic regression analysis (model 1: continuous genetic imbalance), adjusted for age, sex and ancestry-derived principal components 1–10 as potential confounders, and including stroke etiology (TOAST/CCS) and stroke severity (NIHSS) as additional covariates. NIHSS indicates NIH stroke scale; TOAST, Trial of Org 10172 in Acute Stroke Treatment stroke sub classification; CCS, Causative Classification System; OR, model-adjusted odds ratio of favorable outcome; 95%CI: 95% confidence interval of OR

^§percentage in brackets

^$range in square brackets.

Univariate p-values obtained by non-model-based methods: χ²-squared test, Student’s t test or Mann-Whitney U-test, as appropriate