Table 5.
SI and RF Values of 13a1–2, 13c1–4, 13d1 and 13f1
| compd | SI (RF)a |
|||||
|---|---|---|---|---|---|---|
| L100I | K103N | Y181C | Y188L | E138K | F227L+V106A | |
| 13a1 | 2880 (1.2) | 2835 (1.3) | 2071 (1.7) | 1645 (2.2) | 1298 (2.7) | 1220 (2.9) |
| 13a2 | 9576 (3.3) | 28912 (1.1) | 17281 (1.8) | 6594 (4.8) | 9515 (3.3) | 3999 (7.9) |
| 13c1 | 8941 (1.1) | 9220 (1.0) | 5087 (1.9) | 1810 (5.3) | 3471 (2.7) | 2270 (4.2) |
| 13c2 | >104167 (1.5) | >277778 (0.6) | >56818 (2.8) | >29762 (5.3) | >35714 (4.4) | >13158 (11.9) |
| 13c3 | 9050 (1.8) | 15221 (1.0) | 6318 (2.5) | 3940 (4.0) | 3986 (4.0) | 4349 (3.7) |
| 13c4 | 9035 (1.8) | 31212 (0.5) | 7630 (2.1) | 4769 (3.3) | 6023 (2.6) | 3576 (4.4) |
| 13d1 | >39683 (5.3) | >21186 (10) | >16447 (12.9) | >16667 (12.7) | >5543 (38.4) | >6579 (32.3) |
| 13f1 | ≥11488 (4.7) | ≥28500 (1.9) | ≥14250 (3.8) | ≥18525 (3.0) | ≥17435 (3.1) | ≥6645 (8.3) |
| ETV | >755 (1.1) | >1379 (0.6) | >315 (2.3) | >225 (3.3) | >471 (1.6) | >233 (3.2) |
a
RF is the ratio of EC50(resistant viral strain)/EC50(wild-type viral strain).