Table 3.
The relationship between 4-lncRNA signature and Clinical characteristics in the three NSCLC patient cohorts
| Characteristics | Discovery cohort (N = 194) | Validation cohort (N = 172) | Independent cohort (N = 73) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low-risk | High-risk | P value | Low-risk | High-risk | P value | Low-risk | High-risk | P value | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
| Age | |||||||||
| ≥ 60 | 52 (53.6) | 49 (50.5) | 0.706 | 49 (57.0) | 46 (53.5) | 0.816 | 19 (51.4) | 21 (58.3) | 0.493 |
| < 60 | 45 (46.4) | 48 (49.5) | 37 (43.0) | 40 (46.5) | 18 (48.6) | 15 (41.7) | |||
| Gender | |||||||||
| Male | 82 (84.5) | 72 (74.2) | 0.269 | 67 (77.9) | 69 (80.2) | 0.374 | 29 (78.4) | 23 (63.9) | 0.290 |
| Female | 15 (15.5) | 25 (25.8) | 19 (22.1) | 17 (19.8) | 8 (21.6) | 13 (36.1) | |||
| TNM stage | |||||||||
| I | 46 (47.4) | 41 (42.3) | 0.637 | 39 (45.3) | 35 (40.7) | 0.702 | 13 (35.1) | 10 (27.8) | 0.518 |
| II | 11 (11.3) | 21 (21.6) | 18 (21.0) | 16 (18.6) | 8 (21.6) | 12 (33.3) | |||
| III | 40 (41.2) | 35 (36.1) | 29 (33.7) | 35 (40.7) | 16 (43.2) | 14 (38.9) | |||
| Histological type | |||||||||
| ADC | 55 (56.7) | 40 (41.2) | 0.304 | 39 (45.3) | 50 (58.1) | 0.297 | 25 (67.6) | 22 (61.1) | 0.451 |
| SCC | 39 (40.2) | 49 (50.5) | 40 (46.5) | 36 (41.9) | 12 (32.4) | 14 (38.9) | |||
| ADC/SCC | 3 (3.1) | 8 (8.3) | 7 (8.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |||
| Tumor size (cm) | |||||||||
| < 5 | 59 (60.8) | 49 (50.5) | 0.332 | 46 (53.5) | 51 (59.3) | 0.573 | 13 (35.1) | 18 (50.0) | 0.197 |
| ≥ 5 | 38 (39.2) | 48 (49.5) | 40 (46.5) | 35 (40.7) | 24 (64.9) | 18 (50.0) | |||
| Differentiation | |||||||||
| Well/moderate | 58 (59.8) | 68 (70.1) | 0.402 | 44 (51.2) | 61 (70.9) | 0.203 | 19 (51.4) | 24 (66.7) | 0.310 |
| Poor | 39 (40.2) | 29 (29.9) | 42 (48.8) | 25 (29.1) | 18 (48.6) | 12 (33.3) | |||
| Lymph metastasis | |||||||||
| No | 47 (48.5) | 58 (59.8) | 0.257 | 39 (45.3) | 42 (48.8) | 0.574 | 21 (56.8) | 24 (66.7) | 0.297 |
| Yes | 50 (51.5) | 39 (40.2) | 47(54.7) | 44 (51.2) | 16 (43.2) | 12 (33.3) | |||
| Smoking history | |||||||||
| No | 36 (37.1) | 43 (44.3) | 0.503 | 29 (33.7) | 33 (38.4) | 0.692 | 15 (40.5) | 18 (50.0) | 0.307 |
| Yes | 61 (62.9) | 54 (55.7) | 57 (66.3) | 53 (61.6) | 22 (59.5) | 18 (50.0) | |||
| Fam. cancer hist. | |||||||||
| No | 84 (86.6) | 77 (79.3) | 0.396 | 73 (75.3) | 78 (90.7) | 0.417 | 36 (97.3) | 35 (97.2) | 0.664 |
| Yes | 13 (13.4) | 20 (20.7) | 13 (13.4) | 8 (9.3) | 1 (2.7) | 1 (2.8) | |||
Fam. cancer hist. Family cancer history