Table 6.
Multivariate Cox regression analysis of the impact of lncRNA signature and clinicopathological features on OS and DFS in the three NSCLC patient cohorts
| Dataset | Parameters | Overall survival | Disease-free survival | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Training | Signature | 3.18 (1.62–6.23) | 0.001 | 2.17 (1.35–3.47) | 0.001 |
| Age | 1.07 (0.78–1.45) | 0.401 | 1.03 (0.76–1.40) | 0.845 | |
| Gender | 1.61 (0.57–4.51) | 0.365 | 1.42 (0.54–3.73) | 0.474 | |
| TNM stages | 1.61 (1.09–2.15) | 0.008 | 1.47 (1.06–2.05) | 0.022 | |
| Histological types | 0.99 (0.61–1.61) | 0.965 | 0.94 (0.58–1.51) | 0.783 | |
| Tumor sizes | 0.91 (0.47–1.73) | 0.767 | 0.86 (0.45–1.64) | 0.657 | |
| Differentiation | 1.18 (0.78–1.78) | 0.43 | 1.12 (0.75–1.68) | 0.587 | |
| Pleural invasion | 1.60 (0.85–3.01) | 0.147 | 1.79 (0.96–3.35) | 0.068 | |
| Vascular invasion | 2.17 (0.75–6.28) | 0.154 | 1.86 (0.65–5.34) | 0.248 | |
| Smoking history | 2.94 (1.15–7.50) | 0.024 | 2.60 (1.09–6.24) | 0.032 | |
| Fam. cancer hist. | 0.58 (0.25–1.37) | 0.218 | 0.53 (0.23–1.25) | 0.146 | |
| Validation | Signature | 2.41 (1.47–3.97) | 0.001 | 2.49 (1.53–4.05) | <0.001 |
| Age | 1.14 (0.87–1.49) | 0.359 | 1.13 (0.87–1.48) | 0.349 | |
| Gender | 0.64 (0.32–1.27) | 0.201 | 0.79 (0.41–1.55) | 0.498 | |
| TNM stages | 1.40 (1.03–1.91) | 0.031 | 1.40 (1.04–1.88) | 0.026 | |
| Histological types | 0.92 (0.62–1.38) | 0.697 | 0.94 (0.63–1.4) | 0.763 | |
| Tumor sizes | 1.41 (0.80–2.49) | 0.240 | 1.27 (0.73–2.23) | 0.402 | |
| Differentiation | 0.89 (0.59–1.32) | 0.552 | 0.88 (0.60–1.31) | 0.537 | |
| Pleural invasion | 1.42 (0.85–2.39) | 0.185 | 1.51 (0.90–2.52) | 0.116 | |
| Vascular invasion | 5.40 (1.73–16.8) | 0.004 | 4.91 (1.59–15.17) | 0.006 | |
| Smoking history | 0.54 (0.28–1.04) | 0.064 | 0.52 (0.27–1.00) | 0.050 | |
| Fam. cancer hist. | 1.22 (0.66–2.28) | 0.521 | 1.48 (0.81–2.70) | 0.206 | |
| Independent | Signature | 1.88 (1.15–3.08) | 0.012 | 1.80 (1.14–2.84) | 0.012 |
| Age | 1.00 (0.70–1.42) | 0.988 | 1.19 (0.86–1.66) | 0.294 | |
| Gender | 0.80 (0.46–1.40) | 0.430 | 0.70 (0.42–1.18) | 0.183 | |
| TNM stages | 1.80 (1.28–2.54) | 0.001 | 1.69 (1.24–2.30) | 0.001 | |
| Histological types | 1.26 (0.74–2.13) | 0.395 | 1.12 (0.69–1.84) | 0.640 | |
| Tumor sizes | 1.78 (1.06–2.97) | 0.028 | 1.92 (1.19–3.09) | 0.008 | |
| Differentiation | 1.66 (1.03–2.66) | 0.037 | 1.81 (1.16–2.83) | 0.009 | |
| Pleural invasion | 1.26 (0.68–2.33) | 0.466 | 1.59 (0.87–2.91) | 0.130 | |
| Vascular invasion | 1.75 (0.39–7.92) | 0.468 | 2.81 (0.79–9.98) | 0.110 | |
Italic P values represent the statistic significance
Fam. cancer hist. Family cancer history