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Space between radial glial fibres in the IZ. The average space between (A) GFAP and (B) Vimentin labelled radial glial fibres in the IZ across mid-gestation in age-matched euploid (black squares) and Down syndrome (grey circles) cases. Photomicrographs of GFAP staining across mid-gestation in (C–E) euploid and (F–H) Down syndrome cases. Scale bars indicate (C–H) 100 µm. IZ intermediate zone, PMA post-menstrual age
