Table 3.
CRYAB and HOPX staining in the Ventricular and Subventricular Zones during mid-gestation in Down syndrome and age-matched euploid control brains
| Cases | PMA (weeks + days) | CRYAB | HOPX | ||
|---|---|---|---|---|---|
| VZ/iSVZ | oSVZ | VZ/iSVZ | oSVZ | ||
| Aged-match euploid control | |||||
| E-1 | 18 + 0 | Peri-nuclear, along ventricle | X | Sparse | Yes |
| E-2 | 22 + 2 | Peri-nuclear, heterogeneous expression | continuous radial projection | Sparse | Yes |
| E-3 | 23 + 0 | Peri-nuclear, along ventricle | X | Sparse | Yes |
| E-4 | 23 + 2 | Peri-nuclear, along ventricle | Punctate radial projections | Sparse | Yes |
| E-5 | 24 + 1 | Strong radial, away from ventricle - perinuclear, tails to positive cells | X | Sparse | Yes |
| Down syndrome | |||||
| DS-1 | 15 + 6 | X | X | Sparse | Yes |
| DS-2 | 18 + 4 | Peri-nuclear and radial | X | Sparse | Yes |
| DS-5 | 19 + 5 | Peri-nuclear along ventricle | Punctate radial projections | Sparse | Yes |
| DS-4 | 21 + 1 | Cellular, peri-nuclear and radial | Punctate radial projections | Sparse | Yes |
| DS-5 | 22 + 5 | X | X | Sparse | Yes |
| DS-6 | 23 + 4 | X | X | Sparse | Yes |
E euploid, DS down syndrome, PMA post-menstrual age, VZ ventricular zone, iSVZ inner subventricular zone, oSVZ subventricular zone. X = no positive staining present, Sparse = few cells; yes = frequent number of cells