Table 2.
Univariate and multivariate Cox regression analysis of clinical-factors/risk-score with overall survival rate in patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| TCGA-BLCA | ||||
| Age | 1.04 (1.02–1.06) | 1.20E−05 | 1.02 (0.99–1.05) | 2.69E−01 |
| Gender | 1.11 (0.78-1.58) | 5.56E−01 | 1.44 (0.81–2.54) | 2.14E−01 |
| Grade | 9,608,547.45 (0-Inf) | 9.91E−01 | 5,878,954.98 (0-Inf) | 9.96E−01 |
| Stage | 1.81 (1.47-2.23) | 2.62E−08 | 0.89 (0.42–1.88) | 7.63E−01 |
| T stage | 1.75 (1.37-2.24) | 6.57E−06 | 1.38 (0.82–2.34) | 2.23E−01 |
| Node | 1.61 (1.35-1.91) | 8.06E−08 | 1.44(0.86-2.41) | 1.64E−01 |
| Metastasis | 3.06 (1.39-6.73) | 5.44E−03 | 0.88(0.28-2.72) | 8.24E−01 |
| Risk score | 3.75 (2.43-5.79) | 2.46E−09 | 4.1(1.89-8.91) | 3.67E−04 |
| GSE13507 | ||||
| Age | 1.07 (1.04–1.1) | 4.53E−08 | 1.07 (1.04–1.1) | 8.71E−06 |
| Gender | 1.56 (0.88–2.77) | 1.29E−01 | 1.57 (0.81–3.03) | 1.81E−01 |
| Grade | 1.9 (1.49–2.42) | 2.46E−07 | 1 (0.54–1.86) | 9.97E−01 |
| Stage | 2.74 (1.69–4.43) | 4.00E−05 | 1.06 (0.52–2.14) | 8.70E−01 |
| T stage | 2.05 (1.64–2.58) | 5.06E−10 | 1.51 (0.82–2.79) | 1.83E−01 |
| Node | 3.32 (2.23–4.94) | 3.88E−09 | 2.21 (1.09–4.46) | 2.71E−02 |
| Metastasis | 9.9 (4.38–22.37) | 3.64E−08 | 3.61 (1.2–10.86) | 2.21E−02 |
| Risk score | 11.16 (4.22–29.47) | 1.14E−06 | 1.33 (0.26–6.87) | 7.37E−01 |
| GSE32548 | ||||
| Age | 1.04 (0.99–1.08) | 9.34E−02 | 1.06 (1.01–1.1) | 2.00E−02 |
| Gender | 0.78 (0.29–2.07) | 6.13E−01 | 0.66 (0.23–1.85) | 4.27E−01 |
| Grade | 2.26 (1.07–4.77) | 3.26E−02 | 0.46 (0.15–1.44) | 1.83E−01 |
| T stage | 3.53 (1.89–6.6) | 7.42E−05 | 3.97 (1.58–9.99) | 3.41E−03 |
| Risk score | 43.5 (6.85–276.49) | 6.37E−05 | 12.81 (1.06–154.42) | 4.46E−02 |
| GSE32894 | ||||
| Age | 0.98 (0.95–1.01) | 1.79E−01 | 0.97 (0.92–1.01) | 1.63E−01 |
| Gender | 1.47 (0.55–3.93) | 4.45E−01 | 1.35 (0.49–3.74) | 5.61E−01 |
| Grade | 7.59 (2.45–23.52) | 4.45E−04 | 3.58 (1.05–12.13) | 4.08E−02 |
| T stage | 0.98 (0.62–1.56) | 9.42E−01 | 1 (0.58–1.7) | 9.86E−01 |
| Risk score | 140.69 (25.35–780.79) | 1.54E−08 | 31.03 (3.79–253.97) | 1.36E−03 |
Italic font means statistically significant
HR hazard ratio, CI confidence interval, Inf infinity