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. Author manuscript; available in PMC: 2021 Jan 24.

Published in final edited form as: J Nat Prod. 2019 Dec 20;83(1):134–141. doi: 10.1021/acs.jnatprod.9b00993

Table 2.

Anti-HIV Activity and Cytotoxicity of Nine Daphnane Diterpenes^a

	anti-HIV	cytotoxicity	selectivity index
compound	IC_5O (nM)	CC₅₀ (μM)	CC₅₀/IC₅₀
2	62.9 ± 14.7	>6.6	>105
4	2.0 ± 0.5	>6.6	>3320
11	<0.9	>6.8	>8035
12	<0.9	>6.8	>8035
14	5.3 ± 1.8	>6.8	>1288
16	805.0 ± 164.5	>6.7	>8
24	1.2 ± 0.3	>6.2	>5144
25	<0.8	>6.4	>7962
27	<0.8	>6.2	>7987
azt^b	20.0 ± 5.6	>15.0	>750

^a

Values are mean ± SD (n = 3).

^b

Positive control substance.