Table 3.
Relative differences (%) in dosimetric parameters of the GTV, PTV and 2 cm ring around the PTV (‘Ring’), between the adapted plans and the reference plans. All mean changes larger than 1% are marked in bold. GTV: Gross Tumor Volume, PTV: Planning Target Volume, SD: Standard Deviation
| ALL | Abdomen | Liver | Liver (non-SBRT) | Lung | Prostate | Prostate (non-SBRT) | Pelvis | |
|---|---|---|---|---|---|---|---|---|
| GTV | ||||||||
| Dmean | ||||||||
| Median [range] | 0.14 [−9.0–4.7] | −0.11 [−9.0–4.7] | 0.23 [−2.5–3.4] | − 0.23 [− 0.98–0.56] | 0.46 [− 1.9–4.6] | 0.19 [− 1.2–2.3] | − 0.44 [− 1.1–1.3] | 0.18 [− 2.5–1.5] |
| Mean ± SD | 0.06 ± 1.5 | − 0.26 ± 2.1 | 0.35 ± 1.4 | − 0.17 ± 0.44 | 0.42 ± 1.3 | 0.40 ± 0.79 | − 0.21 ± 0.70 | 0.00 ± 1.1 |
| P-value | 0.04 | 0.56 | 0.21 | 0.31 | 0.06 | 0.005 | 0.16 | 0.61 |
| D95% | ||||||||
| Median [range] | − 0.11 [− 25.8–31.3] | −0.35 [− 25.8–31.3] | 0.44 [− 8.7–5.8] | − 0.46 [− 1.2–0.78] | 0.20 [− 2.2–5.4] | −0.03 [− 0.85–4.1] | −0.43 [− 1.2–1.3] | 0.15 [− 1.7–1.5] |
| Mean ± SD | − 0.09 ± 4.5 | − 0.68 ± 7.4 | 0.42 ± 2.7 | −0.34 ± 0.64 | 0.41 ± 1.5 | 0.38 ± 1.2 | −0.32 ± 0.66 | 0.09 ± 0.72 |
| P-value | 0.71 | 0.008 | 0.14 | 0.10 | 0.21 | 0.27 | 0.07 | 0.46 |
| D98% | ||||||||
| Median [range] | −0.19 [− 23.7–44.7] | −0.57 [− 23.7–44.7] | 0.53 [−9.3–10.8] | − 0.69 [− 2.7–0.92] | 0.18 [− 2.1–5.4] | −0.04 [− 1.3–6.3] | −0.43 [− 1.2–1.1] | 0.03 [− 2.4–1.6] |
| Mean ± SD | 0.04 ± 5.3 | −0.40 ± 8.6 | 0.47 ± 4.0 | −0.61 ± 1.0 | 0.48 ± 1.5 | 0.63 ± 1.9 | −0.30 ± 0.64 | −0.03 ± 0.89 |
| P-value | 0.34 | 0.002 | 0.15 | 0.08 | 0.11 | 0.39 | 0.08 | 0.97 |
| D2% | ||||||||
| Median [range] | 0.46 [−11.6–4.4] | 0.65 [− 11.6–4.4] | 0.29 [− 3.2–2.7] | 0.22 [− 0.42–1.0] | 0.29 [− 2.7–2.9] | 0.64 [− 1.5–4.2] | −0.43 [− 1.3–1.7] | 0.47 [− 3.7–2.1] |
| Mean ± SD | 0.40 ± 1.5 | 0.42 ± 2.0 | 0.36 ± 1.3 | 0.30 ± 0.41 | 0.37 ± 1.46 | 0.85 ± 1.0 | − 0.02 ± 0.90 | 0.07 ± 1.4 |
| P-value | < 0.0001 | 0.007 | 0.26 | 0.03 | 0.10 | < 0.0001 | 0.95 | 0.30 |
| PTV | ||||||||
| Dmean | ||||||||
| Median [range] | 0.08 [−8.6–5.4] | − 0.11 [− 8.6–5.4] | 0.23 [− 5.0–2.2] | −0.17 [− 1.3–0.23] | 0.31 [− 2.4–3.2] | 0.19 [− 1.2–1.3] | −0.17 [− 0.65–0.00] | 0.24 [− 2.1–1.9] |
| Mean ± SD | 0.01 ± 1.5 | −0.29 ± 2.1 | 0.16 ± 1.6 | −0.26 ± 0.57 | 0.40 ± 1.3 | 0.27 ± 0.46 | −0.22 ± 0.25 | 0.09 ± 1.1 |
| P-value | 0.02 | 0.54 | 0.13 | 0.12 | 0.05 | < 0.0001 | 0.007 | 0.26 |
| D95% | ||||||||
| Median [range] | 0.00 [− 26.4–13.4] | −0.26 [− 12.9–18.4] | 0.18 [− 26.4–6.2] | − 0.34 [− 5.1–0.24] | −0.02 [− 2.0–4.4] | 0.03 [− 0.86–1.2] | −0.05 [− 0.89–1.1] | 0.36 [− 1.3–2.6] |
| Mean ± SD | −0.24 ± 3.6 | −0.55 ± 5.2 | −0.56 ± 5.8 | − 1.1 ± 1.7 | 0.08 ± 1.2 | 0.10 ± 0.44 | − 0.05 ± 0.55 | 0.37 ± 0.96 |
| P-value | 0.95 | 0.12 | 0.33 | 0.02 | 0.98 | 0.26 | 0.70 | 0.06 |
| D98% | ||||||||
| Median [range] | −0.04 [−31.6–25.4] | −0.19 [− 18.9–25.4] | −0.14 [− 31.6–24.4] | −0.33 [− 29.7–0.21] | −0.18[− 21.0–5.5] | 0.18[− 2.4–5.9] | −0.16[− 2.0–1.4] | 0.16[− 2.6–2.2] |
| Mean ± SD | −0.25 ± 5.4 | −0.18 ± 5.7 | 0.37 ± 8.9 | −5.4 ± 10.8 | −0.57 ± 3.6 | 0.74 ± 1.9 | −0.15 ± 0.77 | 0.40 ± 1.17 |
| P-value | 0.46 | 0.21 | 0.95 | 0.03 | 0.18 | 0.04 | 0.41 | 0.09 |
| D2% | ||||||||
| Median [range] | 0.26[−43.6–3.9] | 0.32[− 3.3–3.6] | 0.25[− 43.6–3.1] | 0.10[− 0.23–0.86] | 0.38[− 2.5–3.9] | 0.51[−1.6–3.7] | −0.29[− 1.4–0.96] | 0.31[−3.7–2.1] |
| Mean ± SD | 0.14 ± 3.1 | 0.37 ± 1.4 | −1.3 ± 8.7 | 0.15 ± 0.30 | 0.41 ± 1.5 | 0.62 ± 0.91 | − 0.10 ± 0.67 | −0.11 ± 1.5 |
| P-value | < 0.0001 | 0.04 | 0.21 | 0.17 | 0.15 | < 0.0001 | 0.80 | 0.71 |
| Ring | ||||||||
| Dmean | ||||||||
| Median [range] | 0.80[−15.8–13.1] | 1.0[−7.2–8.4] | 1.6[− 4.5–8.1] | −0.28[− 4.7–2.7] | 0.80[−4.2–7.8] | − 0.17[− 15.8–6.8] | 0.00[− 10.0–2.7] | 1.5[− 1.9–13.1] |
| Mean ± SD | 1.0 ± 3.6 | 1.4 ± 3.2 | 1.6 ± 3.4 | −0.14 ± 2.2 | 1.8 ± 2.9 | −0.89 ± 5.3 | −0.51 ± 2.7 | 2.5 ± 3.4 |
| P-value | < 0.0001 | 0.0002 | 0.05 | 0.89 | 0.01 | 0.89 | 0.85 | 0.001 |
| D5% | ||||||||
| Median [range] | 0.56 [−10.5–6.8] | 0.72[− 4.3–6.0] | 0.21[− 2.0–6.8] | 0.00[−1.7–0.86] | 1.6[−3.5–4.9] | − 0.10[− 10.5–3.0] | 0.34[− 1.1–1.9] | 1.3[− 0.24–5.8] |
| Mean ± SD | 0.64 ± 2.1 | 0.71 ± 1.5 | 0.90 ± 2.1 | − 0.07 ± 0.79 | 1.3 ± 2.0 | −0.70 ± 3.3 | 0.35 ± 0.78 | 1.6 ± 1.4 |
| P-value | < 0.0001 | < 0.0001 | 0.11 | 0.84 | 0.002 | 0.86 | 0.11 | < 0.0001 |