Table 3.

A hierarchical regression of serum UA predicting cognitive function in male CHF patients (n = 121)

	Cognitive function
	β	95% CI		R2	ΔR2	P-value
		Lower	Upper
Block 1	–	–	–	0.519	–	0.000**
Age	−0.286	−0.453	− 0.119			0.001**
Educational level	0.287	0.142	0.432			0.000**
NYHA function class	−0.051	−0.201	0.099			0.501
LVEF	−0.080	−0.235	0.074			0.304
BMI	0.074	−0.081	0.229			0.344
Hemoglobin	−0.098	−0.259	0.062			0.228
hs-CRP	−0.140	−0.282	0.003			0.054
eGFR	0.028	−0.122	0.179			0.712
Hypertension	−0.046	−0.188	0.097			0.528
Type 2 diabetes mellitus	0.026	−0.112	0.165			0.710
Atrial fibrillation	−0.174	−0.329	− 0.019			0.029*
SDS score	−0.293	−0.459	− 0.126			0.001**
Block 2	–	–	–	0.568	0.049	0.001**
Serum UA	−0.247	−0.388	− 0.106			0.001**

UA uric acid, CHF chronic heart failure, NYHA New York Heart Association, LVEF left ventricular fraction, BMI body mass index, hs-CRP hypersensitive C-reactive protein, eGFR estimated glomerular filtration rate, SDS self-rating depression scale

β standardized coefficients, CI confidence interval

* P < 0.05; ** P < 0.01