Table 3.

Impact of TTI on locoregional control and index cancer-specific hazard (N = 197 patients with 207 tumors): a multivariate analysis

Parameter	HR	95% CI	P-value
Locoregional control
TNM (III vs. I-II)	0.843	0.369–1.925	0.685
TNM (IV vs. I-II)	2.320	1.211–4.444	0.011
Age	0.976	0.950–1.002	0.075
TTI	1.012	0.998–1.027	0.094
Gender	0.501	0.201–1.249	0.138
Therapy (CCT vs. RT)	0.768	0.444–1.328	0.344
Cause specific hazard
TNM (III vs. I-II)	3.203	1.286–7.976	0.012
TNM (IV vs. I-II)	13.223	6.007–29.108	< 0.001
Age	0.985	0.965–1.005	0.133
TTI	1.001	0.990–1.012	0.844
Gender	0.907	0.529–1.556	0.724
Therapy (CCT vs. RT)	0.534	0.369–0.774	0.001

CI Confidence interval; TTI Time to treatment intervention;

CCT Concurrent chemoradiotherapy; RT Radiotherapy