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. 2020 Aug 20;17:245. doi: 10.1186/s12974-020-01917-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Panx1 deletion in myeloid cells reduces biomarkers of TBI. Brain tissue was isolated from ipsilateral cortex from each group and protein expression levels were determined by western blot at 6-days post-injury: a Representative western blots images showing α II spectrin and its spectrin breakdown product (SBDP 120 kDa and SBDP 140 kDa) levels at 6 days post-injury in both sham and CCI-injured Cx3cr1-Cre::Panx1^fl/fl and Panx1^fl/fl mice. The bottom western blot corresponds to the GAPDH, which was used as a housekeeping gene. The graph shows densitometric quantification of SBDP 120 kDa normalized to GAPDH values. Values are represented as mean ± SD (n = 4 to 8 per group). One-way ANOVA (F_3,19 = 8.237) and Tukey’s post hoc test. b Representative western blots images showing MMP-9 levels at 6 days post-injury in both sham and CCI-injured Cx3cr1-Cre::Panx1^fl/fl and Panx1^fl/fl mice. The bottom western blot corresponds to the GAPDH, which was used as a housekeeping gene. The graph shows densitometric quantification of MMP-9 normalized to GAPDH values. Values are represented as mean ± SD (n = 4 to 8 per group). Values are expressed as the mean ± SD optical density relative to GAPDH. *P < 0.05, **P < 0.01, One-way ANOVA (F_3,17 = 8.864) and Tukey’s post hoc test.