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. 2020 Aug 20;17:245. doi: 10.1186/s12974-020-01917-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Panx1 deletion in myeloid cells reduces blood–brain barrier leakage after TBI. a Immunoglobulin (IgG) heavy chain and light chain, markers for blood–brain barrier damage, are reduced in Cx3cr1-Cre::Panx1^fl/fl mice (n = 5) compared with Panx1^fl/fl mice (n = 5). Light chain: *P < 0.05, ***P < 0.001, One-way ANOVA (F_{3, 14} = 12.04) and Tukey’s post hoc test. Heavy chain: **P < 0.01, ***P < 0.001, One-way ANOVA (F_3,14 = 16.89) and Tukey’s post hoc test. Values are expressed as mean ± SD optical density relative to GAPDH. Each dot represents an individual animal. b Magnevist present into the parenchyma was calculated by subtracting basal Magnevist in the parenchyma from post-dose. Unpaired Student’s two-tailed t test (t = 4.361, df = 8, P = 0.0024). Values are expressed as the mean difference in (±SD) Magnevist signal before and after dose. Each dot represents an individual animal. *P < 0.05.