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. 2020 May 11;11(21):5577–5591. doi: 10.1039/c9sc06383h

Table 2. Cellular uptake of linear, stapled and stitched dPMI-δ peptides.

Peptide dPMI-δ dPMI-δ(1–5) dPMI-δ(2–6) dPMI-δ(2–9) dPMI-δ(5–9) dPMI-δ(6–10) dPMI-δ(5–12) ATSP-7041
P53 activity EC50 (μM) (2% FBS, 16 h) >50 13.7 (1.2) >50 >50 >50 30.3 (3.1) 21.3 (2.6) 4.2 (2.1)
LDH release EC50 (μM) (2% FBS, 16 h) >50 24 (3) 17.7 (1.9) >50 46.5 (1.2) 18.5 (0.7) >50 >50
Counter screen EC50 (μM) (2% FBS, 16 h) >50 >50 13.9 (4.2) >50 47 (3.0) 39 (4.0) >50 >50