Table 2. Cellular uptake of linear, stapled and stitched dPMI-δ peptides.
| Peptide | dPMI-δ | dPMI-δ(1–5) | dPMI-δ(2–6) | dPMI-δ(2–9) | dPMI-δ(5–9) | dPMI-δ(6–10) | dPMI-δ(5–12) | ATSP-7041 |
| P53 activity EC50 (μM) (2% FBS, 16 h) | >50 | 13.7 (1.2) | >50 | >50 | >50 | 30.3 (3.1) | 21.3 (2.6) | 4.2 (2.1) |
| LDH release EC50 (μM) (2% FBS, 16 h) | >50 | 24 (3) | 17.7 (1.9) | >50 | 46.5 (1.2) | 18.5 (0.7) | >50 | >50 |
| Counter screen EC50 (μM) (2% FBS, 16 h) | >50 | >50 | 13.9 (4.2) | >50 | 47 (3.0) | 39 (4.0) | >50 | >50 |