. 2020 Apr 30;11(25):6500–6509. doi: 10.1039/d0sc01349h

Table 2. Assessment of forming 3a in 2-MeTHF and Gly when the order of addition of reagents is 2a then 1a ^a .


Entry	Solvent	Time	Yield [%]
1	Gly	10 s	32
2	Gly	30 s	3
3	2-MeTHF	1 min	70
4		2 min	62
5		5 min	42
6		10 min	13

^aReactions performed in air at ambient temperature using 1 g of solvent and 1 mmol of 1a. Lithium amide 2a was added as a 1 M soln. in 2-MeTHF and stirred for the specified time before addition of 1a. Reactions stirred for another 20 s, then quenched with sat. Rochelle's salt soln. (5 mL). Isolated yields are given.

Table 2. Assessment of forming 3a in 2-MeTHF and Gly when the order of addition of reagents is 2a then 1a a .

Table 2. Assessment of forming 3a in 2-MeTHF and Gly when the order of addition of reagents is 2a then 1a ^a .