Supplementary Table 1.
Description of the early death for patients with IV breast cancer in the validation cohort.
| Subject characteristics | Patients No. (%) | |||
|---|---|---|---|---|
| No early death | Total early death | Cancer specific early death | Non-cancer specifi early death | |
| Age | ||||
| <50 | 600 (20.8) | 64 (9.3) | 51 (10.0) | 13 (7.2) |
| 50–59 | 655 (22.7) | 131 (19) | 101 (19.9) | 30 (16.6) |
| 60–69 | 771 (26.7) | 178 (25.8) | 136 (26.8) | 42 (23.2) |
| 70–79 | 527 (18.2) | 133 (19.3) | 97 (19.1) | 36 (19.9) |
| ≥80 | 337 (11.7) | 183 (26.6) | 123 (24.2) | 60 (33.1) |
| Marital status | ||||
| Married | 1341 (46.4) | 213 (30.9) | 164 (32.3) | 49 (27.1) |
| Unmarried | 1390 (48.1) | 441 (64) | 321 (63.2) | 120 (66.3) |
| Unknown | 159 (5.5) | 35 (5.1) | 23 (4.5) | 12 (6.6) |
| Race | ||||
| White | 2206 (76.3) | 498 (72.3) | 369 (72.6) | 129 (71.3) |
| Black | 402 (13.9) | 147 (21.3) | 109 (21.5) | 38 (21) |
| Others | 260 (9.0) | 41 (6.0) | 27 (5.3) | 14 (7.7) |
| Unknown | 22 (0.8) | 3 (0.4) | 3 (0.6) | 0 (0) |
| Insurance | ||||
| Insured | 2737 (94.7) | 640 (92.9) | 466 (91.7) | 174 (96.1) |
| Uninsured | 75 (2.6) | 31 (4.5) | 27 (5.3) | 4 (2.2) |
| Unknown | 78 (2.7) | 18 (2.6) | 15 (3.0) | 3 (1.7) |
| Subtypes | ||||
| Luminal A | 1612 (55.8) | 239 (34.7) | 174 (34.3) | 65 (35.9) |
| Luminal B | 476 (16.5) | 76 (11.0) | 58 (11.4) | 18 (9.9) |
| HER2 enriched | 222 (7.7) | 55 (8.0) | 42 (8.3) | 13 (7.2) |
| Triple negative | 295 (10.2) | 110 (16.0) | 76 (15.0) | 34 (18.8) |
| Unknown | 285 (9.9) | 209 (30.3) | 158 (31.1) | 51 (28.2) |
| Grade | ||||
| Grade I | 204 (7.1) | 27 (3.9) | 22 (4.3) | 5 (2.8) |
| Grade II | 1065 (36.9) | 139 (20.2) | 98 (19.3) | 41 (22.7) |
| Grade III | 1006 (34.8) | 233 (33.8) | 172 (33.9) | 61 (33.7) |
| Grade IV | 5 (0.2) | 3 (0.4) | 2 (0.4) | 1 (0.6) |
| Unknown | 610 (21.1) | 287 (41.7) | 214 (42.1) | 73 (40.3) |
| Tumor site | ||||
| UOQ | 764 (26.4) | 128 (18.6) | 93 (18.3) | 35 (19.3) |
| LOQ | 162 (5.6) | 19 (2.8) | 12 (2.4) | 7 (3.9) |
| LIQ | 98 (3.4) | 20 (2.9) | 12 (2.4) | 8 (4.4) |
| UIQ | 161 (5.6) | 32 (4.6) | 24 (4.7) | 8 (4.4) |
| CEN | 188 (6.5) | 32 (4.6) | 26 (5.1) | 6 (3.3) |
| Others | 577 (20.0) | 116 (16.8) | 86 (16.9) | 30 (16.6) |
| Unknown | 940 (32.5) | 342 (49.6) | 255 (50.2) | 87 (48.1) |
| Laterality | ||||
| Left-sided | 1371 (47.4) | 312 (45.3) | 233 (45.9) | 79 (43.6) |
| Right-sided | 1387 (48.0) | 310 (45.0) | 226 (44.5) | 84 (46.4) |
| One side, NOS | 10 (0.3) | 3 (0.4) | 2 (0.4) | 1 (0.6) |
| Paired sides | 122 (4.2) | 64 (9.3) | 47 (9.3) | 17 (9.4) |
| Tumor size | ||||
| 0–2 cm | 414 (14.3) | 86 (12.5) | 63 (12.4) | 23 (12.7) |
| 2–5 cm | 1076 (37.2) | 196 (28.4) | 138 (27.2) | 58 (32.0) |
| >5 cm | 794 (27.5) | 177 (25.7) | 138 (27.2) | 39 (21.5) |
| Unknown | 606 (21.0) | 230 (33.4) | 169 (33.3) | 61 (33.7) |
| N stage | ||||
| N0 | 664 (23) | 196 (28.4) | 142 (28.0) | 54 (29.8) |
| N1 | 1200 (41.5) | 243 (35.3) | 180 (35.4) | 63 (34.8) |
| N2 | 329 (11.4) | 53 (7.7) | 40 (7.9) | 13 (7.2) |
| N3 | 430 (14.9) | 74 (10.7) | 60 (11.8) | 14 (7.7) |
| Unknown | 267 (9.2) | 123 (17.9) | 86 (16.9) | 37 (20.4) |
| Bone Met | ||||
| No | 1014 (35.1) | 254 (36.9) | 166 (32.7) | 88 (48.6) |
| Yes | 1876 (64.9) | 435 (63.1) | 342 (67.3) | 93 (51.4) |
| Brain Met | ||||
| No | 2747 (95.1) | 612 (88.8) | 448 (88.2) | 164 (90.6) |
| Yes | 143 (4.9) | 77 (11.2) | 60 (11.8) | 17 (9.4) |
| Liver Met | ||||
| No | 2289 (79.2) | 411 (59.7) | 282 (55.5) | 129 (71.3) |
| Yes | 601 (20.8) | 278 (40.3) | 226 (44.5) | 52 (28.7) |
| Lung Met | ||||
| No | 2055 (71.1) | 423 (61.4) | 306 (60.2) | 117 (64.6) |
| Yes | 835 (28.9) | 266 (38.6) | 202 (39.8) | 64 (35.4) |
| Surgery | ||||
| No Surgery | 2127 (73.6) | 633 (91.9) | 467 (91.9) | 166 (91.7) |
| PM | 220 (7.6) | 18 (2.6) | 13 (2.6) | 5 (2.8) |
| TM | 240 (8.3) | 17 (2.5) | 13 (2.6) | 4 (2.2) |
| RM | 263 (9.1) | 16 (2.3) | 12 (2.4) | 4 (2.2) |
| Others | 14 (0.5) | 0 (0) | 0 (0) | 0 (0) |
| Unknown | 26 (0.9) | 5 (0.7) | 3 (0.6) | 2 (1.1) |
UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM – radical mastectomy.