Table 3.
Multivariate logistic regression for analyzing the risk factors for early death in patients with IV breast cancer.
| Subject characteristics | Total early death | Cancer specific early death | Non-cancer specific early death | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age | ||||||
| <50 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| 50–59 | 1.59 (1.35–1.89) | <0.001 | 1.51 (1.26–1.80) | <0.001 | 1.52 (1.09–2.13) | 0.014 |
| 60–69 | 2.22 (1.88–2.63) | <0.001 | 1.84 (1.54–2.20) | <0.001 | 2.5 (1.83–3.44) | <0.001 |
| 70–79 | 3.48 (2.90–4.17) | <0.001 | 2.41 (1.98–2.93) | <0.001 | 4.25 (3.08–5.86) | <0.001 |
| ≥80 | 7.04 (5.78–8.57) | <0.001 | 3.95 (3.21–4.87) | <0.001 | 7.37 (5.31–10.22) | <0.001 |
| Marital status | ||||||
| Married | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Unmarried | 1.40 (1.26–1.56) | <0.001 | 1.39 (1.23–1.56) | <0.001 | 1.19 (1–1.42) | 0.052 |
| Race | ||||||
| White | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Black | 1.36 (1.19–1.57) | <0.001 | 1.28 (1.10–1.48) | 0.001 | 1.34 (1.08–1.67) | 0.009 |
| Others | 0.91 (0.74–1.12) | 0.381 | 0.94 (0.75–1.17) | 0.570 | 0.88 (0.61–1.27) | 0.505 |
| Insurance | ||||||
| Insured | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Uninsured | 1.31 (1.00–1.72) | 0.048 | 1.52 (1.15–2.00) | 0.003 | 0.61 (0.33–1.11) | 0.103 |
| Subtypes | ||||||
| Luminal A | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Luminal B | 0.78 (0.67–0.91) | 0.002 | 0.81 (0.68–0.96) | 0.014 | 0.83 (0.63–1.08) | 0.164 |
| HER2 enriched | 1.17 (0.97–1.42) | 0.107 | 1.11 (0.90–1.36) | 0.318 | 1.23 (0.9–1.69) | 0.193 |
| Triple Negative | 3.76 (3.23–4.37) | <0.001 | 3.06 (2.62–3.57) | <0.001 | 2.09 (1.66–2.62) | <0.001 |
| Grade | ||||||
| Grade I | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Grade II | 1.56 (1.25–1.95) | <0.001 | 1.59 (1.22–2.06) | 0.001 | 1.27 (0.91–1.79) | 0.165 |
| Grade III | 2.22 (1.76–2.79) | <0.001 | 2.29 (1.76–2.99) | <0.001 | 1.42 (1–2.02) | 0.053 |
| Grade IV | 1.44 (0.70–2.93) | 0.321 | 1.95 (0.94–4.07) | 0.075 | 0.57 (0.13–2.49) | 0.454 |
| Laterality | ||||||
| Left-sided | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Right-sided | 0.99 (0.90–1.10) | 0.888 | 1.00 (0.89–1.12) | 0.998 | 0.98 (0.83–1.15) | 0.768 |
| One side, NOS | – | 1.000 | – | 1.000 | – | 1.000 |
| Paired sides | 2.66 (0.72–9.79) | 0.142 | 2.45 (0.67–8.94) | 0.176 | 1.28 (0.15–10.76) | 0.821 |
| Tumor size | ||||||
| 0–2 cm | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| 2–5 cm | 1.05 (0.91–1.22) | 0.519 | 1.21 (1.02–1.43) | 0.027 | 0.82 (0.66–1.02) | 0.070 |
| >5 cm | 1.32 (1.13–1.54) | 0.001 | 1.69 (1.42–2.01) | <0.001 | 0.67 (0.53–0.86) | 0.001 |
| N stage | ||||||
| N0 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| N1 | 0.77 (0.67–0.89) | <0.001 | 0.97 (0.84–1.13) | 0.731 | 0.56 (0.45–0.69) | <0.001 |
| N2 | 0.82 (0.67–1.01) | 0.066 | 0.91 (0.72–1.14) | 0.419 | 0.77 (0.56–1.06) | 0.112 |
| N3 | 0.94 (0.81–1.09) | 0.395 | 1.03 (0.87–1.20) | 0.769 | 0.84 (0.67–1.05) | 0.117 |
| Bone Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 1.11 (0.99–1.24) | 0.088 | 1.15 (1.02–1.31) | 0.027 | 0.91 (0.76–1.1) | 0.325 |
| Brain Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 3.67 (3.04–4.40) | <0.001 | 2.94 (2.44–3.54) | <0.001 | 2.03 (1.55–2.65) | <0.001 |
| Liver Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 2.28 (2.03–2.56) | <0.001 | 2.2 (1.95–2.48) | <0.001 | 1.41 (1.17–1.7) | <0.001 |
| Lung Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 1.30 (1.16–1.45) | <0.001 | 1.36 (1.21–1.53) | <0.001 | 0.96 (0.8–1.15) | 0.675 |
| Surgery | ||||||
| No surgery | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| PM | 0.46 (0.38–0.56) | <0.001 | 0.44 (0.35–0.54) | <0.001 | 0.76 (0.57–1) | 0.049 |
| TM | 0.42 (0.34–0.51) | <0.001 | 0.41 (0.32–0.52) | <0.001 | 0.71 (0.52–0.98) | 0.036 |
| RM | 0.39 (0.33–0.46) | <0.001 | 0.41 (0.34–0.49) | <0.001 | 0.59 (0.45–0.77) | <0.001 |
| Others | 0.75 (0.29–1.94) | 0.557 | 0.65 (0.22–1.93) | 0.435 | 1.23 (0.28–5.34) | 0.786 |
SEER – Surveillance, Epidemiology, and End Result; OR – odds ratio; CI – confidence interval; Ref – reference; NA – not applicable; UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM = radical mastectomy.