Table 3.

Physicochemical properties and drug-likeness of the most promising cyanobacterial metabolites.

Cyanobacterial compound	Mol. wt. (Dalton)	Number of hydrogen bond acceptors	Number of hydrogen bond donors	Log P	Solubility	PAINS Alerts	Bioavailability	Mutagenicity (AMES mutagenesis)	Cytotoxicity
Apratoxin A	840.12	9	2	4.38	Poorly soluble	0 alert	0.17	No	No
Carrageenan	551.83	10	3	−9.41	Moderately Soluble	0 alert	0.17	No	No
Cryptophycin 1	655.18	8	2	4.65	Poorly soluble	0 alert	0.55	No	No
Cryptophycin 52	699.20	8	2	4.84	Poorly soluble	0 alert	0.55	No	No
Cylindrospermopsin	415.42	8	5	−1.37	Highly soluble	0 alert	0.55	No	No
Deoxycylindrospermopsin	399.42	7	4	−0.55	Highly soluble	0 alert	0.55	No	No
Eucapsitrione	358.30	6	3	2.57	Moderately soluble	0 alert	0.55	No	No
Tjipanazole A1	471.33	4	4	3.65	Moderately soluble	0 alert	0.55	Yes	No
Tolyporphin	742.83	12	4	2.67	Poorly soluble	0 alert	0.17	No	No

Log P-Logarithm of partial coefficient; PAINS-Pan-Assay Interference Structures.