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Physicochemical parameters of the X77-mimetic candidates associated with the Lipinski's “rule of five”.
| Ligand | Chemical formula | Molecular mass (Da) | LogP | Number of H-bond donors | Number of H-bond acceptors |
|---|---|---|---|---|---|
| I | C21H25N3O4 | 384.,00 | 2.225 | 3 | 6 |
| II | C19H26N6O5 | 419.00 | −1.206 | 3 | 9 |
| III | C19H21N5O3 | 368.00 | 0.146 | 5 | 6 |
| IV | C21H24N6O6 | 456.00 | 0.071 | 5 | 11 |
| V | C17H20ClN5O3 | 378.00 | −1.090 | 3 | 6 |
